TY - JOUR
T1 - Immunosuppression may be present within condyloma acuminata
AU - Le Poole, Caroline
AU - Denman, Cecele J.
AU - Arbiser, Jack L.
N1 - Copyright:
Copyright 2009 Elsevier B.V., All rights reserved.
PY - 2008/12
Y1 - 2008/12
N2 - Background: Condyloma acuminatum are common lesions caused by human papillomavirus (HPV). HPV is associated with many human cancers, and a vaccine now prevents infection with high-risk HPV. However, eradication of established disease is difficult, indicating that these lesions are capable of local immunosuppression. Objective: This study examines the immunohistochemical staining characteristics of condyloma acuminatum lesions for markers of cellular immunity, including T-lymphocyte subsets, dendritic cells, and infected keratinocytes and markers of antigen presentation in condyloma tissue. Methods: Five snap-frozen, optimal cutting temperature-embedded condyloma lesions were immunostained for T-lymphocyte markers Fox P3, CD8, CD25 and molecules involved in antigen presentation. Results: Condylomas demonstrated hallmarks of immunosuppression, such as increased cellular interleukin-10 production, decreased expression of transporter associated with antigen presentation, CD40, and carbonic anhydrase IX, decreased dendritic cell counts, and increased T-regulatory cell infiltration. Limitations: This study was performed with lesions from a single center, and control tissue from the same patients was not available because of lack of patient consent. Conclusion: These results demonstrate that condylomas induce a local immunosuppressive environment, with deficits in antigen presentation and enhancement of immunosuppressive T-regulatory cell populations. Strategies to block this immunosuppression are required to elicit effective immune responses to HPV infection.
AB - Background: Condyloma acuminatum are common lesions caused by human papillomavirus (HPV). HPV is associated with many human cancers, and a vaccine now prevents infection with high-risk HPV. However, eradication of established disease is difficult, indicating that these lesions are capable of local immunosuppression. Objective: This study examines the immunohistochemical staining characteristics of condyloma acuminatum lesions for markers of cellular immunity, including T-lymphocyte subsets, dendritic cells, and infected keratinocytes and markers of antigen presentation in condyloma tissue. Methods: Five snap-frozen, optimal cutting temperature-embedded condyloma lesions were immunostained for T-lymphocyte markers Fox P3, CD8, CD25 and molecules involved in antigen presentation. Results: Condylomas demonstrated hallmarks of immunosuppression, such as increased cellular interleukin-10 production, decreased expression of transporter associated with antigen presentation, CD40, and carbonic anhydrase IX, decreased dendritic cell counts, and increased T-regulatory cell infiltration. Limitations: This study was performed with lesions from a single center, and control tissue from the same patients was not available because of lack of patient consent. Conclusion: These results demonstrate that condylomas induce a local immunosuppressive environment, with deficits in antigen presentation and enhancement of immunosuppressive T-regulatory cell populations. Strategies to block this immunosuppression are required to elicit effective immune responses to HPV infection.
UR - http://www.scopus.com/inward/record.url?scp=55949097978&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=55949097978&partnerID=8YFLogxK
U2 - 10.1016/j.jaad.2008.08.011
DO - 10.1016/j.jaad.2008.08.011
M3 - Article
C2 - 19022100
AN - SCOPUS:55949097978
SN - 0190-9622
VL - 59
SP - 967
EP - 974
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
IS - 6
ER -