Immunotherapy for malignant glioma: Current approaches and future directions

Christian W. Sikorski, Maciej S. Lesniak*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations

Abstract

Traditional therapies for the treatment of malignant glioma have failed to make appreciable gains regarding patient outcome in the last decade. Therefore, immunotherapeutic approaches have become increasingly popular in the treatment of this cancer. This article reviews general immunology of the central nervous system and the immunobiology of malignant glioma to provide a foundation for understanding the rationale behind current glioma immunotherapies. A review of currently implemented immunological treatments is then provided with special attention paid to the use of vaccines, gene therapy, cytokines, dendritic cells and viruses. Insights into future and developing avenues of glioma immunotherapy, such as novel delivery systems, are also discussed.

Original languageEnglish (US)
Pages (from-to)703-716
Number of pages14
JournalNeurological research
Volume27
Issue number7
DOIs
StatePublished - Oct 1 2005

Keywords

  • Cytokines
  • Dendritic cells
  • Gene therapy
  • Glioma
  • Immunotherapy
  • Neuroimmunology
  • Vaccine
  • Virus

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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