Immunotherapy for pediatric brain tumors: Past and present

Jessica B. Foster, Peter J. Madsen, Meenakshi Hegde, Nabil Ahmed, Kristina A. Cole, John M. Maris, Adam C. Resnick, Phillip B. Storm, Angela J. Waanders*

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

The field of cancer immunotherapy has progressed at an accelerated rate over the past decade. Pediatric brain tumors thus far have presented a formidable challenge for immunotherapy development, given their typically low mutational burden, location behind the blood-brain barrier in a unique tumor microenvironment, and intratumoral heterogeneity. Despite these challenges, recent developments in the field have resulted in exciting preclinical evidence for various immunotherapies and multiple clinical trials. This work reviews the history and advances in active immunotherapy, checkpoint blockade, and adoptive T-cell therapy for pediatric brain tumors, including ongoing clinical trials.

Original languageEnglish (US)
Pages (from-to)1226-1238
Number of pages13
JournalNeuro-oncology
Volume21
Issue number10
DOIs
StatePublished - 2019

Keywords

  • Brain tumor
  • Immunotherapy
  • Pediatric

ASJC Scopus subject areas

  • Oncology
  • Clinical Neurology
  • Cancer Research

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  • Cite this

    Foster, J. B., Madsen, P. J., Hegde, M., Ahmed, N., Cole, K. A., Maris, J. M., Resnick, A. C., Storm, P. B., & Waanders, A. J. (2019). Immunotherapy for pediatric brain tumors: Past and present. Neuro-oncology, 21(10), 1226-1238. https://doi.org/10.1093/neuonc/noz077