Immunotherapy for Soft Tissue Sarcoma: Tomorrow Is Only a Day Away

Alex Lee, Paul Huang, Ronald P. DeMatteo, Seth M. Pollack

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Despite the advances taking place for patients with many types of cancer, to date there has been little success in meeting the great need for novel treatments of advanced soft tissue sarcoma with effective immunologic therapies. Here, we review recent clinical and preclinical data that indicate immune responses against sarcomas occur spontaneously and can also be successfully provoked. Efforts to manipulate the sarcoma immune microenvironment have the potential to eradicate disease and may also sensitize tumors to other tumor-targeted immunotherapeutic approaches. Other approaches, including vaccines and genetic engineering of T cells, offer a promising opportunity to actively direct cytotoxic lymphocytes toward antigen-bearing sarcomas. Drawing parallels with recent advances made in other cancer types, we identify ways in which sarcomas can be included in the ongoing immunotherapy revolution.

Original languageEnglish (US)
Pages (from-to)281-290
Number of pages10
JournalAmerican Society of Clinical Oncology educational book. American Society of Clinical Oncology. Meeting
Volume35
DOIs
StatePublished - 2016
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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