Immunotherapy in food allergy

Toral Kamdar, Paul J. Bryce

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations

Abstract

Food allergies are caused by immune responses to food proteins and represent a breakdown of oral tolerance. They can range from mild pruritis to life-threatening anaphylaxis. The only current consensus for treatment is food avoidance, which is fraught with compliance issues. For this reason, there has been recent interest in immunotherapy, which may induce desensitization and possibly even tolerance. Through these effects, immunotherapy may decrease the potential for adverse serious reactions with accidental ingestions while potentially leading to an overall health benefit. In this review, we discuss the mechanisms of food allergy and give an overview of the various immunotherapeutic options and current supporting evidence, as well as look towards the future of potential novel therapeutic modalities.

Original languageEnglish (US)
Pages (from-to)329-338
Number of pages10
JournalImmunotherapy
Volume2
Issue number3
DOIs
StatePublished - May 2010

Keywords

  • Food allergy
  • Food hypersensitivity
  • Immunotherapy
  • Oral immunotherapy
  • Sublingual immunotherapy

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Oncology

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