Efforts to improve conventional immunotherapy by allergen modification have generally followed one of three approaches. (1) Impedance of allergen release from site of injection, an example being alum-precipitation, has been somewhat successful. (2) Suppression of specific IgE has been unsuccessful in human trials. (3) Reduction of allergenicity with retention of immunogenicity appears to be the most promising, polymerized allergens and allergoid being examples. There are some reports of combining modifications. Modified extracts can be standardized. The specific tests to be used depend, in part, on characterization of the unique modification of the allergen.
|Original language||English (US)|
|Number of pages||11|
|Journal||Immunology and Allergy Clinics of North America|
|State||Published - Jan 1 1992|
ASJC Scopus subject areas
- Immunology and Allergy