Immunotherapy with tacrolimus (FK506) does not select for resistance to calcineurin inhibitors in Candida albicans isolates from liver transplant patients

Jennifer L. Reedy, Shahid Husain, Michael Ison, Timothy L. Pruett, Nina Singh, Joseph Heitman*

*Corresponding author for this work

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

In Candida albicans, calcineurin mediates tolerance to azole antifungal drugs, survival in serum, and virulence. In this study, we examined 24 Candida isolates from liver transplant recipients receiving a calcineurin inhibitor as a component of their immunosuppressive therapy. We were unable to detect a difference in susceptibility to calcineurin inhibitors in combination with fluconazole, serum, or calcium in these isolates.

Original languageEnglish (US)
Pages (from-to)1573-1577
Number of pages5
JournalAntimicrobial agents and chemotherapy
Volume50
Issue number4
DOIs
StatePublished - Apr 1 2006

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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