ImmVar project: Insights and design considerations for future studies of "healthy" immune variation

Philip L. De Jager*, Nir Hacohen, Diane Mathis, Aviv Regev, Barbara Elaine Stranger, Christophe Benoist

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

31 Scopus citations

Abstract

The Immune Variation (ImmVar) project is one of a series of recent efforts to map the extent of variation in immune function in healthy human subjects. The focus of our initial studies involved a careful mapping of the genetic architecture of the adaptive and innate immunologic transcriptomes. Our studies highlight the shared nature of this immunogenetic architecture across human populations, the important role of context in uncovering effects of genetic variation, and the fact that, over all tested genes, common genetic variation account for a minority of the variance in the immune transcriptome in healthy subjects. Yet, it is an element of the variance that can be measured very precisely and will play an important role in the design of future studies. We therefore discuss how insights from ImmVar and similar studies inform experimental strategies and frame the design of future studies of immune function in health and disease.

Original languageEnglish (US)
Pages (from-to)51-57
Number of pages7
JournalSeminars in Immunology
Volume27
Issue number1
DOIs
StatePublished - Feb 1 2015

Keywords

  • EQTL
  • Genetic architecture
  • Genetic variation
  • Healty immune variation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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