Impact of age and cardiac disease on regional left and right ventricular myocardial motion in healthy controls and patients with repaired tetralogy of fallot

Alexander Ruh*, Roberto Sarnari, Haben Berhane, Kenny Sidoryk, Kai Lin, Ryan Dolan, Arleen Li, Michael J. Rose, Joshua D Robinson, James Carr, Cynthia K Rigsby, Michael Markl

*Corresponding author for this work

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The assessment of both left (LV) and right ventricular (RV) motion is important to understand the impact of heart disease on cardiac function. The MRI technique of tissue phase mapping (TPM) allows for the quantification of regional biventricular three-directional myocardial velocities. The goal of this study was to establish normal LV and RV velocity parameters across a wide range of pediatric to adult ages and to investigate the feasibility of TPM for detecting impaired regional biventricular function in patients with repaired tetralogy of Fallot (TOF). Thirty-six healthy controls (age = 1–75 years) and 12 TOF patients (age = 5–23 years) underwent cardiac MRI including TPM in short-axis locations (base, mid, apex). For ten adults, a second TPM scan was used to assess test–retest reproducibility. Data analysis included the calculation of biventricular radial, circumferential, and long-axis velocity components, quantification of systolic and diastolic peak velocities in an extended 16 + 10 LV + RV segment model, and assessment of inter-ventricular dyssynchrony. Biventricular velocities showed good test–retest reproducibility (mean bias ≤ 0.23 cm/s). Diastolic radial and long-axis peak velocities for LV and RV were significantly reduced in adults compared to children (19–61%, p < 0.001–0.02). In TOF patients, TPM identified significantly reduced systolic and diastolic LV and RV long-axis peak velocities (20–50%, p < 0.001–0.05) compared to age-matched controls. In conclusion, tissue phase mapping enables comprehensive analysis of global and regional biventricular myocardial motion. Changes in myocardial velocities associated with age underline the importance of age-matched controls. This pilot study in TOF patients shows the feasibility to detect regionally abnormal LV and RV motion.

Original languageEnglish (US)
Pages (from-to)1119-1132
Number of pages14
JournalInternational Journal of Cardiovascular Imaging
Volume35
Issue number6
DOIs
StatePublished - Jun 1 2019

Fingerprint

Tetralogy of Fallot
Heart Diseases
Pediatrics

Keywords

  • Biventricular myocardial velocities
  • Cardiovascular magnetic resonance
  • Children
  • Inter-ventricular dyssynchrony
  • Repaired tetralogy of Fallot
  • Tissue phase mapping

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

@article{bcd9992a523d4174b0ba9622b3c1b231,
title = "Impact of age and cardiac disease on regional left and right ventricular myocardial motion in healthy controls and patients with repaired tetralogy of fallot",
abstract = "The assessment of both left (LV) and right ventricular (RV) motion is important to understand the impact of heart disease on cardiac function. The MRI technique of tissue phase mapping (TPM) allows for the quantification of regional biventricular three-directional myocardial velocities. The goal of this study was to establish normal LV and RV velocity parameters across a wide range of pediatric to adult ages and to investigate the feasibility of TPM for detecting impaired regional biventricular function in patients with repaired tetralogy of Fallot (TOF). Thirty-six healthy controls (age = 1–75 years) and 12 TOF patients (age = 5–23 years) underwent cardiac MRI including TPM in short-axis locations (base, mid, apex). For ten adults, a second TPM scan was used to assess test–retest reproducibility. Data analysis included the calculation of biventricular radial, circumferential, and long-axis velocity components, quantification of systolic and diastolic peak velocities in an extended 16 + 10 LV + RV segment model, and assessment of inter-ventricular dyssynchrony. Biventricular velocities showed good test–retest reproducibility (mean bias ≤ 0.23 cm/s). Diastolic radial and long-axis peak velocities for LV and RV were significantly reduced in adults compared to children (19–61{\%}, p < 0.001–0.02). In TOF patients, TPM identified significantly reduced systolic and diastolic LV and RV long-axis peak velocities (20–50{\%}, p < 0.001–0.05) compared to age-matched controls. In conclusion, tissue phase mapping enables comprehensive analysis of global and regional biventricular myocardial motion. Changes in myocardial velocities associated with age underline the importance of age-matched controls. This pilot study in TOF patients shows the feasibility to detect regionally abnormal LV and RV motion.",
keywords = "Biventricular myocardial velocities, Cardiovascular magnetic resonance, Children, Inter-ventricular dyssynchrony, Repaired tetralogy of Fallot, Tissue phase mapping",
author = "Alexander Ruh and Roberto Sarnari and Haben Berhane and Kenny Sidoryk and Kai Lin and Ryan Dolan and Arleen Li and Rose, {Michael J.} and Robinson, {Joshua D} and James Carr and Rigsby, {Cynthia K} and Michael Markl",
year = "2019",
month = "6",
day = "1",
doi = "10.1007/s10554-019-01544-6",
language = "English (US)",
volume = "35",
pages = "1119--1132",
journal = "International Journal of Cardiovascular Imaging",
issn = "1569-5794",
publisher = "Springer Netherlands",
number = "6",

}

Impact of age and cardiac disease on regional left and right ventricular myocardial motion in healthy controls and patients with repaired tetralogy of fallot. / Ruh, Alexander; Sarnari, Roberto; Berhane, Haben; Sidoryk, Kenny; Lin, Kai; Dolan, Ryan; Li, Arleen; Rose, Michael J.; Robinson, Joshua D; Carr, James; Rigsby, Cynthia K; Markl, Michael.

In: International Journal of Cardiovascular Imaging, Vol. 35, No. 6, 01.06.2019, p. 1119-1132.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Impact of age and cardiac disease on regional left and right ventricular myocardial motion in healthy controls and patients with repaired tetralogy of fallot

AU - Ruh, Alexander

AU - Sarnari, Roberto

AU - Berhane, Haben

AU - Sidoryk, Kenny

AU - Lin, Kai

AU - Dolan, Ryan

AU - Li, Arleen

AU - Rose, Michael J.

AU - Robinson, Joshua D

AU - Carr, James

AU - Rigsby, Cynthia K

AU - Markl, Michael

PY - 2019/6/1

Y1 - 2019/6/1

N2 - The assessment of both left (LV) and right ventricular (RV) motion is important to understand the impact of heart disease on cardiac function. The MRI technique of tissue phase mapping (TPM) allows for the quantification of regional biventricular three-directional myocardial velocities. The goal of this study was to establish normal LV and RV velocity parameters across a wide range of pediatric to adult ages and to investigate the feasibility of TPM for detecting impaired regional biventricular function in patients with repaired tetralogy of Fallot (TOF). Thirty-six healthy controls (age = 1–75 years) and 12 TOF patients (age = 5–23 years) underwent cardiac MRI including TPM in short-axis locations (base, mid, apex). For ten adults, a second TPM scan was used to assess test–retest reproducibility. Data analysis included the calculation of biventricular radial, circumferential, and long-axis velocity components, quantification of systolic and diastolic peak velocities in an extended 16 + 10 LV + RV segment model, and assessment of inter-ventricular dyssynchrony. Biventricular velocities showed good test–retest reproducibility (mean bias ≤ 0.23 cm/s). Diastolic radial and long-axis peak velocities for LV and RV were significantly reduced in adults compared to children (19–61%, p < 0.001–0.02). In TOF patients, TPM identified significantly reduced systolic and diastolic LV and RV long-axis peak velocities (20–50%, p < 0.001–0.05) compared to age-matched controls. In conclusion, tissue phase mapping enables comprehensive analysis of global and regional biventricular myocardial motion. Changes in myocardial velocities associated with age underline the importance of age-matched controls. This pilot study in TOF patients shows the feasibility to detect regionally abnormal LV and RV motion.

AB - The assessment of both left (LV) and right ventricular (RV) motion is important to understand the impact of heart disease on cardiac function. The MRI technique of tissue phase mapping (TPM) allows for the quantification of regional biventricular three-directional myocardial velocities. The goal of this study was to establish normal LV and RV velocity parameters across a wide range of pediatric to adult ages and to investigate the feasibility of TPM for detecting impaired regional biventricular function in patients with repaired tetralogy of Fallot (TOF). Thirty-six healthy controls (age = 1–75 years) and 12 TOF patients (age = 5–23 years) underwent cardiac MRI including TPM in short-axis locations (base, mid, apex). For ten adults, a second TPM scan was used to assess test–retest reproducibility. Data analysis included the calculation of biventricular radial, circumferential, and long-axis velocity components, quantification of systolic and diastolic peak velocities in an extended 16 + 10 LV + RV segment model, and assessment of inter-ventricular dyssynchrony. Biventricular velocities showed good test–retest reproducibility (mean bias ≤ 0.23 cm/s). Diastolic radial and long-axis peak velocities for LV and RV were significantly reduced in adults compared to children (19–61%, p < 0.001–0.02). In TOF patients, TPM identified significantly reduced systolic and diastolic LV and RV long-axis peak velocities (20–50%, p < 0.001–0.05) compared to age-matched controls. In conclusion, tissue phase mapping enables comprehensive analysis of global and regional biventricular myocardial motion. Changes in myocardial velocities associated with age underline the importance of age-matched controls. This pilot study in TOF patients shows the feasibility to detect regionally abnormal LV and RV motion.

KW - Biventricular myocardial velocities

KW - Cardiovascular magnetic resonance

KW - Children

KW - Inter-ventricular dyssynchrony

KW - Repaired tetralogy of Fallot

KW - Tissue phase mapping

UR - http://www.scopus.com/inward/record.url?scp=85061032545&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85061032545&partnerID=8YFLogxK

U2 - 10.1007/s10554-019-01544-6

DO - 10.1007/s10554-019-01544-6

M3 - Article

C2 - 30715669

AN - SCOPUS:85061032545

VL - 35

SP - 1119

EP - 1132

JO - International Journal of Cardiovascular Imaging

JF - International Journal of Cardiovascular Imaging

SN - 1569-5794

IS - 6

ER -