Impact of age on basal and diet-induced changes in sympathetic nervous system activity of Fischer rats

E. B. Rappaport, J. B. Young, L. Landsberg

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Studies were performed to assess the effect of age on basal sympathetic nervous system activity and on diet-induced changes in sympathetic activity. The rate of norepinephrine turnover in various tissues was measured as an index of sympathetic nervous system activity. In ad lib fed male Fischer 344 rats aged 3 to 24 months, there were no age-related differences in norepinephrine turnover in heart, liver, kidney or pancreas. Throughout the same age range, norepinephrine turnover was greater in organs of sucrose fed than in organs of fasted animals. Diet-induced changes in sympathetic activity thus persist throughout the age range studied.

Original languageEnglish (US)
Pages (from-to)152-157
Number of pages6
JournalJournals of Gerontology
Volume36
Issue number2
DOIs
StatePublished - Jan 1 1981

ASJC Scopus subject areas

  • Aging

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