Impact of aortopathy and aortic valve disease on 3d blood flow and wall shear stress in the thoracic aorta: As assessed by 4D flow MRI

Michael Markl*, Paul W.M. Fedak, Alex Barker

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Recent advances in magnetic resonance imaging (MRI) allow for the comprehensive visualization and quantification of in vivo aortic 3D hemodynamics using 4D flow MRI. The technique offers the opportunity to derive advanced hemodynamic measures, such as wall shear stress, for an improved characterization of aortic disease beyond simple flow metrics known to be associated with aortopathy and aortic valve disease. This chapter will provide an introduction to 4D flow MRI as it is currently used for blood flow visualization and quantification of flow parameters and wall shear stress in the setting of aortopathy and aortic valve diseases with a focus on congenially abnormal bicuspid aortic valves and aortic stenosis.

Original languageEnglish (US)
Title of host publicationSurgical Management of Aortic Pathology
Subtitle of host publicationCurrent Fundamentals for the Clinical Management of Aortic Disease
PublisherSpringer International Publishing
Pages447-464
Number of pages18
ISBN (Electronic)9783709148747
ISBN (Print)9783709148723
DOIs
StatePublished - Jan 1 2019

Keywords

  • 4D flow MRI
  • Aneurysm
  • Aorta
  • Aortic valve diseases
  • Bicuspid aortic valve
  • Blood flow
  • Dilatation
  • Wall shear stress

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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