Abstract
Background: To determine whether cystatin C accurately reflects renal function in asthma, we investigated serum cystatin C concentrations in a large number of asthmatic patients by adjusting for several confounding factors that might affect serum cystatin C concentrations. Methods: A total of 126 asthmatic patients and 126 healthy volunteers, matched for age and gender, were studied. Results: Serum cystatin C concentrations in symptomatic subjects with asthma were significantly higher than in healthy controls (p<0.001) and asymptomatic subjects with asthma (p=0.007), whereas no significant difference was observed between healthy controls and asymptomatic subjects. In asthmatic subjects, serum cystatin C concentrations were not influenced by inhaled corticosteroid (ICS). However, serum cystatin C concentrations were significantly higher in subjects who were regularly treated by oral corticosteroid (OCS) (p=0.001). Conclusions: Serum cystatin C concentrations are elevated in asthmatic patients; particularly while symptomatic and/or taking OCS but not ICS. Serum cystatin C concentrations may not accurately reflect renal function in those patients.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1367-1371 |
| Number of pages | 5 |
| Journal | Clinical Chemistry and Laboratory Medicine |
| Volume | 50 |
| Issue number | 8 |
| State | Published - Oct 1 2012 |
Keywords
- Asthma
- Asthma control status
- Serum cystatin C
ASJC Scopus subject areas
- Clinical Biochemistry
- Biochemistry, medical