Impact of asthmatic control status on serum cystatin C concentrations

Masahiko Shigemura, Satoshi Konno*, Yasuyuki Nasuhara, Chikara Shimizu, Kazuhiko Matsuno, Masaharu Nishimura

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Background: To determine whether cystatin C accurately reflects renal function in asthma, we investigated serum cystatin C concentrations in a large number of asthmatic patients by adjusting for several confounding factors that might affect serum cystatin C concentrations. Methods: A total of 126 asthmatic patients and 126 healthy volunteers, matched for age and gender, were studied. Results: Serum cystatin C concentrations in symptomatic subjects with asthma were significantly higher than in healthy controls (p<0.001) and asymptomatic subjects with asthma (p=0.007), whereas no significant difference was observed between healthy controls and asymptomatic subjects. In asthmatic subjects, serum cystatin C concentrations were not influenced by inhaled corticosteroid (ICS). However, serum cystatin C concentrations were significantly higher in subjects who were regularly treated by oral corticosteroid (OCS) (p=0.001). Conclusions: Serum cystatin C concentrations are elevated in asthmatic patients; particularly while symptomatic and/or taking OCS but not ICS. Serum cystatin C concentrations may not accurately reflect renal function in those patients.

Original languageEnglish (US)
Pages (from-to)1367-1371
Number of pages5
JournalClinical Chemistry and Laboratory Medicine
Issue number8
StatePublished - Oct 1 2012


  • Asthma
  • Asthma control status
  • Serum cystatin C

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical


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