Impact of Atopic Dermatitis Lesion Location on Quality of Life in Adult Patients in a Real-world Study

Peter A. Lio, Andreas Wollenberg, Jacob P. Thyssen, Evangeline J. Pierce, Maria Jose Rueda, Amy M. DeLozier, Jorge Alfonso Ross Terres, Peter Anderson, Gary Milligan, James Piercy, Jonathan I Silverberg, Carle Paul

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Background: Atopic dermatitis (AD) has a negative impact on patients’ quality of life (QoL). Objective: To report the impact of specific AD lesion locations on QoL in adult patients with AD using real-world data. Methods: The Adelphi US Disease Specific Programme was conducted between January–April 2018. Physicians documented patient demographics/characteristics, AD lesion locations, and body surface area; patients completed questionnaires reporting the impact of lesion locations on QoL. Results: AD severity was moderate in 51.6% of patients and severe in 6.0%. Lesions were commonly identified in more than one location. All AD lesion locations impacted QoL. Visible areas were most bothersome, including head/neck (68%), hands/fingers (58%), front (30%), upper extremities (22%), and lower extremities (16%), with statistically significant associations for a number of Dermatology with Life those Quality that are Index most (DLQI) visible/accessible. items. Itch, soreness, Lesions pain, onDo the and head/neck Not stingingCopy are and also hands/fingers associated (58%) with a demonstrated number of body an areas increased but in impact particular onthe Conclusions: anxiety and In depression patients with dimension AD, quality of the of life EuroQol wasPenalties most 5-Dimension affected in tool. patients Apply with lesions in visible areas, including head/neck, hands/ fingers, and upper extremities, with statistically significant associations for a number of DLQI domains. Physicians should be aware of the burden of AD lesions on QoL and consider having conversations with patients to better understand the impact of these lesions. Prior presentation: 28th Annual European Academy of Dermatology and Venereology Congress; 9–13 October 2019, Madrid, Spain. Poster number P0233.

Original languageEnglish (US)
Pages (from-to)943-948
Number of pages6
JournalJournal of Drugs in Dermatology
Issue number10
StatePublished - Oct 2020

ASJC Scopus subject areas

  • General Medicine


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