Impact of carcinoid syndrome symptoms and long-term use of somatostatin analogs on quality of life in patients with carcinoid syndrome A survey study

Daniel M. Halperin, Lynn Huynh*, Jennifer L. Beaumont, Beilei Cai, Todor Totev, Rachel H. Bhak, Mei S. Duh, Maureen P. Neary, David Cella

*Corresponding author for this work

Research output: Contribution to journalReview article

2 Scopus citations

Abstract

To evaluate association of carcinoid syndrome (CS) symptom burden and somatostatin analog (SSA) duration with quality of life (QoL) using Functional Assessment of Cancer Therapy-General (FACT-G) and Patient-Reported Outcomes Measurement Information System (PROMIS-29) instruments. Adults who received treatment for CS symptoms in the US were recruited to participate in a cross-sectional online survey (July-October, 2016). Demographic, clinical, and QoL questions (FACT-G, 29 CS-related supplemental questions, PROMIS-29) were included. Descriptive and multivariable regression analyses adjusting for demographic and clinical characteristics followed. Most (98%) of the 117 patients received SSAs in the prior month. Multivariable regression analysis showed ≥4 bowel movements/ day (vs <4) and each additional CS symptom was associated with 7.1 (P = .043) and 3.4 (P = .034) point FACT-G total score decreases, respectively. Requiring bed rest (vs normal activity) was associated with significant decreases in FACT-G total score (P < .001). There were similar associations for FACT-G subscales, supplemental questions, and PROMIS-29. After adjustment, FACT-G total score was significantly higher (11.3 points; P = .033) for patients treated with SSA >8 years versus <2.7 years. CS symptom burden was observed to be associated with lower QoL scores, measured by FACT-G. Patients with >8 years SSA treatment duration versus <2.7 years had higher QoL.

Original languageEnglish (US)
Article numbere13390
JournalMedicine (United States)
Volume97
Issue number47
DOIs
StatePublished - Nov 1 2018

Keywords

  • Carcinoid syndrome
  • Neuroendocrine tumor
  • Quality of life
  • Somatostatin analogs

ASJC Scopus subject areas

  • Medicine(all)

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