Impact of diabetes on epidemiology, treatment, and outcomes of patients with heart failure

Alessandra Dei Cas, Sadiya S. Khan, Javed Butler, Robert J. Mentz, Robert O. Bonow, Angelo Avogaro, Diethelm Tschoepe, Wolfram Doehner, Stephen J. Greene, Michele Senni, Mihai Gheorghiade, Gregg C. Fonarow*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

245 Scopus citations


The prevalence of patients with concomitant heart failure (HF) and diabetes mellitus (DM) continues to increase with the general aging of the population. In patients with chronic HF, prevalence of DM is 24% compared with 40% in those hospitalized with worsening HF. Patients with concomitant HF and DM have diverse pathophysiologic, metabolic, and neurohormonal abnormalities that potentially contribute to worse outcomes than those without comorbid DM. In addition, although stable HF outpatients with DM show responses that are similar to those of patients without DM undergoing evidence-based therapies, it is unclear whether hospitalized HF patients with DM will respond similarly to novel investigational therapies. These data support the need to re-evaluate the epidemiology, pathophysiology, and therapy of HF patients with concomitant DM. This paper discusses the role of DM in HF patients and underscores the potential need for the development of targeted therapies.

Original languageEnglish (US)
Pages (from-to)136-145
Number of pages10
JournalJACC: Heart Failure
Issue number2
StatePublished - Feb 1 2015


  • Diabetes mellitus
  • Diabetic cardiomyopathy
  • Heart failure

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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