Impact of diabetes on epidemiology, treatment, and outcomes of patients with heart failure

Alessandra Dei Cas; Sadiya S. Khan; Javed Butler; Robert J. Mentz; Robert O. Bonow; Angelo Avogaro; Diethelm Tschoepe; Wolfram Doehner; Stephen J. Greene; Michele Senni; Mihai Gheorghiade; Gregg C. Fonarow

doi:10.1016/j.jchf.2014.08.004

Impact of diabetes on epidemiology, treatment, and outcomes of patients with heart failure

Alessandra Dei Cas, Sadiya S. Khan, Javed Butler, Robert J. Mentz, Robert O. Bonow, Angelo Avogaro, Diethelm Tschoepe, Wolfram Doehner, Stephen J. Greene, Michele Senni, Mihai Gheorghiade, Gregg C. Fonarow^*

^*Corresponding author for this work

Medicine, Cardiology Division

Research output: Contribution to journal › Review article › peer-review

280 Scopus citations

Abstract

The prevalence of patients with concomitant heart failure (HF) and diabetes mellitus (DM) continues to increase with the general aging of the population. In patients with chronic HF, prevalence of DM is 24% compared with 40% in those hospitalized with worsening HF. Patients with concomitant HF and DM have diverse pathophysiologic, metabolic, and neurohormonal abnormalities that potentially contribute to worse outcomes than those without comorbid DM. In addition, although stable HF outpatients with DM show responses that are similar to those of patients without DM undergoing evidence-based therapies, it is unclear whether hospitalized HF patients with DM will respond similarly to novel investigational therapies. These data support the need to re-evaluate the epidemiology, pathophysiology, and therapy of HF patients with concomitant DM. This paper discusses the role of DM in HF patients and underscores the potential need for the development of targeted therapies.

Original language	English (US)
Pages (from-to)	136-145
Number of pages	10
Journal	JACC: Heart Failure
Volume	3
Issue number	2
DOIs	https://doi.org/10.1016/j.jchf.2014.08.004
State	Published - Feb 1 2015

Keywords

Diabetes mellitus
Diabetic cardiomyopathy
Heart failure

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.jchf.2014.08.004

Cite this

@article{f3bff389ae594d0480b3c0983581904c,

title = "Impact of diabetes on epidemiology, treatment, and outcomes of patients with heart failure",

abstract = "The prevalence of patients with concomitant heart failure (HF) and diabetes mellitus (DM) continues to increase with the general aging of the population. In patients with chronic HF, prevalence of DM is 24% compared with 40% in those hospitalized with worsening HF. Patients with concomitant HF and DM have diverse pathophysiologic, metabolic, and neurohormonal abnormalities that potentially contribute to worse outcomes than those without comorbid DM. In addition, although stable HF outpatients with DM show responses that are similar to those of patients without DM undergoing evidence-based therapies, it is unclear whether hospitalized HF patients with DM will respond similarly to novel investigational therapies. These data support the need to re-evaluate the epidemiology, pathophysiology, and therapy of HF patients with concomitant DM. This paper discusses the role of DM in HF patients and underscores the potential need for the development of targeted therapies.",

keywords = "Diabetes mellitus, Diabetic cardiomyopathy, Heart failure",

author = "{Dei Cas}, Alessandra and Khan, {Sadiya S.} and Javed Butler and Mentz, {Robert J.} and Bonow, {Robert O.} and Angelo Avogaro and Diethelm Tschoepe and Wolfram Doehner and Greene, {Stephen J.} and Michele Senni and Mihai Gheorghiade and Fonarow, {Gregg C.}",

note = "Publisher Copyright: {\textcopyright} 2015 American College of Cardiology Foundation.",

year = "2015",

month = feb,

day = "1",

doi = "10.1016/j.jchf.2014.08.004",

language = "English (US)",

volume = "3",

pages = "136--145",

journal = "JACC: Heart Failure",

issn = "2213-1779",

publisher = "Elsevier BV",

number = "2",

}

TY - JOUR

T1 - Impact of diabetes on epidemiology, treatment, and outcomes of patients with heart failure

AU - Dei Cas, Alessandra

AU - Khan, Sadiya S.

AU - Butler, Javed

AU - Mentz, Robert J.

AU - Bonow, Robert O.

AU - Avogaro, Angelo

AU - Tschoepe, Diethelm

AU - Doehner, Wolfram

AU - Greene, Stephen J.

AU - Senni, Michele

AU - Gheorghiade, Mihai

AU - Fonarow, Gregg C.

PY - 2015/2/1

Y1 - 2015/2/1

N2 - The prevalence of patients with concomitant heart failure (HF) and diabetes mellitus (DM) continues to increase with the general aging of the population. In patients with chronic HF, prevalence of DM is 24% compared with 40% in those hospitalized with worsening HF. Patients with concomitant HF and DM have diverse pathophysiologic, metabolic, and neurohormonal abnormalities that potentially contribute to worse outcomes than those without comorbid DM. In addition, although stable HF outpatients with DM show responses that are similar to those of patients without DM undergoing evidence-based therapies, it is unclear whether hospitalized HF patients with DM will respond similarly to novel investigational therapies. These data support the need to re-evaluate the epidemiology, pathophysiology, and therapy of HF patients with concomitant DM. This paper discusses the role of DM in HF patients and underscores the potential need for the development of targeted therapies.

AB - The prevalence of patients with concomitant heart failure (HF) and diabetes mellitus (DM) continues to increase with the general aging of the population. In patients with chronic HF, prevalence of DM is 24% compared with 40% in those hospitalized with worsening HF. Patients with concomitant HF and DM have diverse pathophysiologic, metabolic, and neurohormonal abnormalities that potentially contribute to worse outcomes than those without comorbid DM. In addition, although stable HF outpatients with DM show responses that are similar to those of patients without DM undergoing evidence-based therapies, it is unclear whether hospitalized HF patients with DM will respond similarly to novel investigational therapies. These data support the need to re-evaluate the epidemiology, pathophysiology, and therapy of HF patients with concomitant DM. This paper discusses the role of DM in HF patients and underscores the potential need for the development of targeted therapies.

KW - Diabetes mellitus

KW - Diabetic cardiomyopathy

KW - Heart failure

UR - http://www.scopus.com/inward/record.url?scp=84922016269&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84922016269&partnerID=8YFLogxK

U2 - 10.1016/j.jchf.2014.08.004

DO - 10.1016/j.jchf.2014.08.004

M3 - Review article

C2 - 25660838

AN - SCOPUS:84922016269

SN - 2213-1779

VL - 3

SP - 136

EP - 145

JO - JACC: Heart Failure

JF - JACC: Heart Failure

IS - 2

ER -

Impact of diabetes on epidemiology, treatment, and outcomes of patients with heart failure

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this