Impact of identification and treatment of depression in heart transplant patients

Ike Okwuosa*, Dara Pumphrey, Jyothy Puthumana, Rachel Maria Brown, William Cotts

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Background. The effects of clinical depression after orthotopic heart transplantation (OHT) are relatively unknown. The purpose of this study was to evaluate the impact of depression on outcomes after OHT. Methods. We performed a single center retrospective review of 102 consecutive patients who underwent OHT at Northwestern Memorial Hospital from June 2005 to October 2009. The diagnosis of depression was obtained from attending physician documentation. The primary endpoints were all-cause mortality (ACM), hospitalizations, and rejection. Results. Of 102 OHT patients, 26 (26%) had depression. Depressed patients were similar in age to nondepressed patients (57.6 years versus 56.9, P=0.79). There was no statistical difference in survival between groups at 5 years after OHT (P=0.94). All-cause hospitalizations were higher in depressed versus nondepressed patients (4.3 versus 2.6 hospitalizations P=0.05). There were no significant differences in hospitalizations between the two groups for the following complications: cardiac (heart failure, edema, arrhythmias, and acute rejection) and infections. There was no significant difference in episodes of 2R and 3R rejection. Conclusion. Early identification and treatment of depression in OHT patients result in outcomes similar to nondepressed patients.

Original languageEnglish (US)
Article number747293
JournalCardiovascular Psychiatry and Neurology
StatePublished - 2014

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Cardiology and Cardiovascular Medicine
  • Psychiatry and Mental health


Dive into the research topics of 'Impact of identification and treatment of depression in heart transplant patients'. Together they form a unique fingerprint.

Cite this