Impact of microgravity and partial gravity on cardiac shape

Ilana Iskovitz, Mohammad Kassemi, James D. Thomas

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The impact of gravitational loading on the cardiac shape is studied numerically through application of two different constitutive models for the cardiac tissue. Transversely isotropic and orthotropic cardiac materials models are incorporated into a finite element heart model that includes a realistic 3D cardiac geometry based on detailed cardiac fiber and sheet micro-architecture. The models are used to predict the cardiac sphericity ratio for different gravitational loadings of Earth, Mars, Moon, and Microgravity. Both the transversely isotropic and the orthotropic material models correctly predict the linear dependence of cardiac sphericity on the gravitational force. However, in comparison to the experimental results, only the orthotropic model predicts the rate and magnitude of the cardiac shape change with gravity accurately. The transversely isotropic tissue model produces a stiffer heart that significantly under-predicts the ultrasound measurements of heart shape change during parabolic flight experiments.

Original languageEnglish (US)
Title of host publication42nd International Conference on Environmental Systems 2012, ICES 2012
StatePublished - Dec 1 2012
Event42nd International Conference on Environmental Systems 2012, ICES 2012 - , United States
Duration: Jul 15 2012Jul 19 2012

Publication series

Name42nd International Conference on Environmental Systems 2012, ICES 2012

Other

Other42nd International Conference on Environmental Systems 2012, ICES 2012
Country/TerritoryUnited States
Period7/15/127/19/12

ASJC Scopus subject areas

  • Environmental Engineering

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