TY - GEN
T1 - Impact of microgravity and partial gravity on cardiac shape
AU - Iskovitz, Ilana
AU - Kassemi, Mohammad
AU - Thomas, James D.
PY - 2012/12/1
Y1 - 2012/12/1
N2 - The impact of gravitational loading on the cardiac shape is studied numerically through application of two different constitutive models for the cardiac tissue. Transversely isotropic and orthotropic cardiac materials models are incorporated into a finite element heart model that includes a realistic 3D cardiac geometry based on detailed cardiac fiber and sheet micro-architecture. The models are used to predict the cardiac sphericity ratio for different gravitational loadings of Earth, Mars, Moon, and Microgravity. Both the transversely isotropic and the orthotropic material models correctly predict the linear dependence of cardiac sphericity on the gravitational force. However, in comparison to the experimental results, only the orthotropic model predicts the rate and magnitude of the cardiac shape change with gravity accurately. The transversely isotropic tissue model produces a stiffer heart that significantly under-predicts the ultrasound measurements of heart shape change during parabolic flight experiments.
AB - The impact of gravitational loading on the cardiac shape is studied numerically through application of two different constitutive models for the cardiac tissue. Transversely isotropic and orthotropic cardiac materials models are incorporated into a finite element heart model that includes a realistic 3D cardiac geometry based on detailed cardiac fiber and sheet micro-architecture. The models are used to predict the cardiac sphericity ratio for different gravitational loadings of Earth, Mars, Moon, and Microgravity. Both the transversely isotropic and the orthotropic material models correctly predict the linear dependence of cardiac sphericity on the gravitational force. However, in comparison to the experimental results, only the orthotropic model predicts the rate and magnitude of the cardiac shape change with gravity accurately. The transversely isotropic tissue model produces a stiffer heart that significantly under-predicts the ultrasound measurements of heart shape change during parabolic flight experiments.
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M3 - Conference contribution
AN - SCOPUS:84880995406
SN - 9781600869341
T3 - 42nd International Conference on Environmental Systems 2012, ICES 2012
BT - 42nd International Conference on Environmental Systems 2012, ICES 2012
T2 - 42nd International Conference on Environmental Systems 2012, ICES 2012
Y2 - 15 July 2012 through 19 July 2012
ER -