Impact of physical activity after cancer diagnosis on survival in patients with recurrent colon cancer

Findings from CALGB 89803/alliance

Justin Jeon, Kaori Sato, Donna Niedzwiecki, Xing Ye, Leonard B. Saltz, Robert J. Mayer, Rex B. Mowat, Renaud Whittom, Alexander Hantel, Al B Benson III, Devin S. Wigler, Daniel Atienza, Michael Messino, Hedy Kindler, Alan Venook, Charles S. Fuchs, Jeffrey A. Meyerhardt*

*Corresponding author for this work

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background The impact of physical activity on survival outcomes in patients with recurrent colon cancer has not been studied. We tested the association between the level of postdiagnosis physical activity and survival outcomes of patients with recurrent colon cancer. Patients and Methods We conducted a prospective observational study of 237 patients with stage III colon cancer who had recurrence of disease. Physical activity was measured approximately 6 months after the completion of therapy (14 months after surgical resection) but before detection of recurrent disease. The primary end point of the study was survival time after recurrence. Results The hazard ratio comparing patients who reported at least 18 metabolic equivalent task (MET) hours per week of physical activity with those engaging in < 3 MET hours per week was 0.71 (95% confidence interval, 0.46-1.11). Increasing total MET hours of physical activity per week was associated with a borderline statistical significance trend for improved survival after recurrence (P =.052). The benefit of physical activity on survival was not significantly modified by sex, body mass index (BMI), number of positive lymph nodes, age, baseline performance status, adjuvant chemotherapy regimen, or recurrence-free survival period. Conclusion To our knowledge, this is the first study investigating the association of physical activity with survival outcome of patients with recurrent colon cancer. Although the association exceeded our predefined P trend <.05 for statistical significance, these findings warrant further studies of physical activity in patients with recurrent colorectal cancer.

Original languageEnglish (US)
Pages (from-to)233-238
Number of pages6
JournalClinical Colorectal Cancer
Volume12
Issue number4
DOIs
StatePublished - Dec 1 2013

Fingerprint

Colonic Neoplasms
Exercise
Survival
Metabolic Equivalent
Neoplasms
Recurrence
Adjuvant Chemotherapy
Observational Studies
Colorectal Neoplasms
Body Mass Index
Lymph Nodes
Prospective Studies
Confidence Intervals

Keywords

  • Cancer recurrence
  • Exercise
  • Physical activity
  • Recurrent colon cancer
  • Survival

ASJC Scopus subject areas

  • Oncology
  • Gastroenterology

Cite this

Jeon, Justin ; Sato, Kaori ; Niedzwiecki, Donna ; Ye, Xing ; Saltz, Leonard B. ; Mayer, Robert J. ; Mowat, Rex B. ; Whittom, Renaud ; Hantel, Alexander ; Benson III, Al B ; Wigler, Devin S. ; Atienza, Daniel ; Messino, Michael ; Kindler, Hedy ; Venook, Alan ; Fuchs, Charles S. ; Meyerhardt, Jeffrey A. / Impact of physical activity after cancer diagnosis on survival in patients with recurrent colon cancer : Findings from CALGB 89803/alliance. In: Clinical Colorectal Cancer. 2013 ; Vol. 12, No. 4. pp. 233-238.
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title = "Impact of physical activity after cancer diagnosis on survival in patients with recurrent colon cancer: Findings from CALGB 89803/alliance",
abstract = "Background The impact of physical activity on survival outcomes in patients with recurrent colon cancer has not been studied. We tested the association between the level of postdiagnosis physical activity and survival outcomes of patients with recurrent colon cancer. Patients and Methods We conducted a prospective observational study of 237 patients with stage III colon cancer who had recurrence of disease. Physical activity was measured approximately 6 months after the completion of therapy (14 months after surgical resection) but before detection of recurrent disease. The primary end point of the study was survival time after recurrence. Results The hazard ratio comparing patients who reported at least 18 metabolic equivalent task (MET) hours per week of physical activity with those engaging in < 3 MET hours per week was 0.71 (95{\%} confidence interval, 0.46-1.11). Increasing total MET hours of physical activity per week was associated with a borderline statistical significance trend for improved survival after recurrence (P =.052). The benefit of physical activity on survival was not significantly modified by sex, body mass index (BMI), number of positive lymph nodes, age, baseline performance status, adjuvant chemotherapy regimen, or recurrence-free survival period. Conclusion To our knowledge, this is the first study investigating the association of physical activity with survival outcome of patients with recurrent colon cancer. Although the association exceeded our predefined P trend <.05 for statistical significance, these findings warrant further studies of physical activity in patients with recurrent colorectal cancer.",
keywords = "Cancer recurrence, Exercise, Physical activity, Recurrent colon cancer, Survival",
author = "Justin Jeon and Kaori Sato and Donna Niedzwiecki and Xing Ye and Saltz, {Leonard B.} and Mayer, {Robert J.} and Mowat, {Rex B.} and Renaud Whittom and Alexander Hantel and {Benson III}, {Al B} and Wigler, {Devin S.} and Daniel Atienza and Michael Messino and Hedy Kindler and Alan Venook and Fuchs, {Charles S.} and Meyerhardt, {Jeffrey A.}",
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Jeon, J, Sato, K, Niedzwiecki, D, Ye, X, Saltz, LB, Mayer, RJ, Mowat, RB, Whittom, R, Hantel, A, Benson III, AB, Wigler, DS, Atienza, D, Messino, M, Kindler, H, Venook, A, Fuchs, CS & Meyerhardt, JA 2013, 'Impact of physical activity after cancer diagnosis on survival in patients with recurrent colon cancer: Findings from CALGB 89803/alliance', Clinical Colorectal Cancer, vol. 12, no. 4, pp. 233-238. https://doi.org/10.1016/j.clcc.2013.06.005

Impact of physical activity after cancer diagnosis on survival in patients with recurrent colon cancer : Findings from CALGB 89803/alliance. / Jeon, Justin; Sato, Kaori; Niedzwiecki, Donna; Ye, Xing; Saltz, Leonard B.; Mayer, Robert J.; Mowat, Rex B.; Whittom, Renaud; Hantel, Alexander; Benson III, Al B; Wigler, Devin S.; Atienza, Daniel; Messino, Michael; Kindler, Hedy; Venook, Alan; Fuchs, Charles S.; Meyerhardt, Jeffrey A.

In: Clinical Colorectal Cancer, Vol. 12, No. 4, 01.12.2013, p. 233-238.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Impact of physical activity after cancer diagnosis on survival in patients with recurrent colon cancer

T2 - Findings from CALGB 89803/alliance

AU - Jeon, Justin

AU - Sato, Kaori

AU - Niedzwiecki, Donna

AU - Ye, Xing

AU - Saltz, Leonard B.

AU - Mayer, Robert J.

AU - Mowat, Rex B.

AU - Whittom, Renaud

AU - Hantel, Alexander

AU - Benson III, Al B

AU - Wigler, Devin S.

AU - Atienza, Daniel

AU - Messino, Michael

AU - Kindler, Hedy

AU - Venook, Alan

AU - Fuchs, Charles S.

AU - Meyerhardt, Jeffrey A.

PY - 2013/12/1

Y1 - 2013/12/1

N2 - Background The impact of physical activity on survival outcomes in patients with recurrent colon cancer has not been studied. We tested the association between the level of postdiagnosis physical activity and survival outcomes of patients with recurrent colon cancer. Patients and Methods We conducted a prospective observational study of 237 patients with stage III colon cancer who had recurrence of disease. Physical activity was measured approximately 6 months after the completion of therapy (14 months after surgical resection) but before detection of recurrent disease. The primary end point of the study was survival time after recurrence. Results The hazard ratio comparing patients who reported at least 18 metabolic equivalent task (MET) hours per week of physical activity with those engaging in < 3 MET hours per week was 0.71 (95% confidence interval, 0.46-1.11). Increasing total MET hours of physical activity per week was associated with a borderline statistical significance trend for improved survival after recurrence (P =.052). The benefit of physical activity on survival was not significantly modified by sex, body mass index (BMI), number of positive lymph nodes, age, baseline performance status, adjuvant chemotherapy regimen, or recurrence-free survival period. Conclusion To our knowledge, this is the first study investigating the association of physical activity with survival outcome of patients with recurrent colon cancer. Although the association exceeded our predefined P trend <.05 for statistical significance, these findings warrant further studies of physical activity in patients with recurrent colorectal cancer.

AB - Background The impact of physical activity on survival outcomes in patients with recurrent colon cancer has not been studied. We tested the association between the level of postdiagnosis physical activity and survival outcomes of patients with recurrent colon cancer. Patients and Methods We conducted a prospective observational study of 237 patients with stage III colon cancer who had recurrence of disease. Physical activity was measured approximately 6 months after the completion of therapy (14 months after surgical resection) but before detection of recurrent disease. The primary end point of the study was survival time after recurrence. Results The hazard ratio comparing patients who reported at least 18 metabolic equivalent task (MET) hours per week of physical activity with those engaging in < 3 MET hours per week was 0.71 (95% confidence interval, 0.46-1.11). Increasing total MET hours of physical activity per week was associated with a borderline statistical significance trend for improved survival after recurrence (P =.052). The benefit of physical activity on survival was not significantly modified by sex, body mass index (BMI), number of positive lymph nodes, age, baseline performance status, adjuvant chemotherapy regimen, or recurrence-free survival period. Conclusion To our knowledge, this is the first study investigating the association of physical activity with survival outcome of patients with recurrent colon cancer. Although the association exceeded our predefined P trend <.05 for statistical significance, these findings warrant further studies of physical activity in patients with recurrent colorectal cancer.

KW - Cancer recurrence

KW - Exercise

KW - Physical activity

KW - Recurrent colon cancer

KW - Survival

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