TY - JOUR
T1 - Impact of prenatal exposure to psychotropic drugs on neonatal outcome in infants of mothers with serious psychiatric illnesses
AU - Sutter-Dallay, Anne Laure
AU - Bales, Mélanie
AU - Pambrun, Elodie
AU - Glangeaud-Freudenthal, Nine M.C.
AU - Wisner, Katherine L.
AU - Verdoux, Hélène
N1 - Publisher Copyright:
© 2015 Physicians Postgraduate Press, Inc.
PY - 2015/7/1
Y1 - 2015/7/1
N2 - Objective: To assess whether prenatal exposure to 4 major classes of psychotropic drugs compared with no exposure differed with respect to neonatal outcome. Method: We used the database collected from 13 motherbaby units (MBUs) by the French Network of MBUs. The Marcé Clinical Checklist was used to collect data from maternal interview and clinical record with respect to maternal demographic and clinical characteristics, prenatal exposure to psychotropic drugs, and neonatal outcome (birth weight, preterm birth, neonatal hospitalization). Multivariate logistic regression was used to explore the independent impact of each therapeutic class of psychotropic drug (antipsychotics, antidepressants, mood stabilizers, and anxiolytics/hypnotics) on infant outcomes. All the models were adjusted for maternal confounding factors. Results: The sample included 1,071 women and their infants. Nearly half (40.2%) used at least 1 psychotropic drug during pregnancy. The risk of low birth weight was increased by antenatal exposure to mood stabilizers (adjusted odds ratio [aOR] = 2.04, 95% confidence interval [CI] = 1.03-4.04, P =.04). The risk of neonatal hospitalization was increased by prenatal exposure to antipsychotics (aOR = 1.74, 95% CI = 1.19-2.54, P =.004), antidepressants (aOR = 1.59, 95% CI = 1.05-2.41, P =.03) or anxiolytics/hypnotics (aOR = 1.89, 95% CI = 1.30- 2.75, P =.001), independent of birth weight and term delivery status. Conclusions: Infants exposed to psychotropic drugs during pregnancy have less optimal neonatal outcome than unexposed infants and should be considered as a high-risk population.
AB - Objective: To assess whether prenatal exposure to 4 major classes of psychotropic drugs compared with no exposure differed with respect to neonatal outcome. Method: We used the database collected from 13 motherbaby units (MBUs) by the French Network of MBUs. The Marcé Clinical Checklist was used to collect data from maternal interview and clinical record with respect to maternal demographic and clinical characteristics, prenatal exposure to psychotropic drugs, and neonatal outcome (birth weight, preterm birth, neonatal hospitalization). Multivariate logistic regression was used to explore the independent impact of each therapeutic class of psychotropic drug (antipsychotics, antidepressants, mood stabilizers, and anxiolytics/hypnotics) on infant outcomes. All the models were adjusted for maternal confounding factors. Results: The sample included 1,071 women and their infants. Nearly half (40.2%) used at least 1 psychotropic drug during pregnancy. The risk of low birth weight was increased by antenatal exposure to mood stabilizers (adjusted odds ratio [aOR] = 2.04, 95% confidence interval [CI] = 1.03-4.04, P =.04). The risk of neonatal hospitalization was increased by prenatal exposure to antipsychotics (aOR = 1.74, 95% CI = 1.19-2.54, P =.004), antidepressants (aOR = 1.59, 95% CI = 1.05-2.41, P =.03) or anxiolytics/hypnotics (aOR = 1.89, 95% CI = 1.30- 2.75, P =.001), independent of birth weight and term delivery status. Conclusions: Infants exposed to psychotropic drugs during pregnancy have less optimal neonatal outcome than unexposed infants and should be considered as a high-risk population.
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U2 - 10.4088/JCP.14m09070
DO - 10.4088/JCP.14m09070
M3 - Article
C2 - 25844580
AN - SCOPUS:84938153543
SN - 0160-6689
VL - 76
SP - 967
EP - 973
JO - Journal of Clinical Psychiatry
JF - Journal of Clinical Psychiatry
IS - 7
ER -