Impact of smoking on patients with stage iii colon cancer: Results from cancer and leukemia group B 89803

Nadine Jackson McCleary, Donna Niedzwiecki, Donna Hollis, Leonard B. Saltz, Paul Schaefer, Renaud Whittom, Alexander Hantel, Al Benson, Richard Goldberg, Jeffrey A. Meyerhardt

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

BACKGROUND: Cigarette smoking has been shown to increase the risk of developing colorectal cancer, particularly smoking early in life. Little is known about the impact of tobacco use on colon cancer recurrence among colon cancer survivors. METHODS: The authors prospectively collected lifetime smoking history from stage III colon cancer patients enrolled in a phase 3 trial via self-report questionnaires during and 6 months after completion of adjuvant chemotherapy. Smoking status was defined as never, current, or past. Lifetime pack-years were defined as number of lifetime packs of cigarettes. Patients were followed for recurrence or death. RESULTS: Data on smoking history were captured on 1045 patients with stage III colon cancer receiving adjuvant therapy (46% never smokers; 44% past; 10% current). The adjusted hazard ratio (HR) for disease-free survival (DFS) was 0.99 (95% confidence interval [CI], 0.70-1.41), 1.17 (95% CI 0.89-1.55), and 1.22 (95% CI 0.92-1.61) for lifetime pack-years 0-10, 10-20, and 20+, respectively, compared with never smoking (P = .16). In a preplanned exploratory analysis of smoking intensity early in life, the adjusted HR for 12+ pack-years before age 30 years for DFS was 1.37 (95% CI, 1.02-1.84) compared with never smoking (P = .04). The adjusted HR for DFS was 1.18 (95% CI, 0.92-1.50) for past smokers and 1.10 (95% CI, 0.73-1.64) for current smokers, compared with never smokers. CONCLUSIONS: Total tobacco usage early in life may be an important, independent prognostic factor of cancer recurrences and mortality in patients with stage III colon cancer.

Original languageEnglish (US)
Pages (from-to)957-966
Number of pages10
JournalCancer
Volume116
Issue number4
DOIs
StatePublished - Feb 15 2010

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Colonic Neoplasms
Leukemia
Smoking
Confidence Intervals
Neoplasms
Disease-Free Survival
Recurrence
History
Tobacco Use
Adjuvant Chemotherapy
Tobacco Products
Self Report
Tobacco
Survivors
Colorectal Neoplasms
Mortality

Keywords

  • Adjuvant chemotherapy
  • Cancer recurrence
  • Cancer survival
  • Colorectal cancer
  • Smoking

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

McCleary, N. J., Niedzwiecki, D., Hollis, D., Saltz, L. B., Schaefer, P., Whittom, R., ... Meyerhardt, J. A. (2010). Impact of smoking on patients with stage iii colon cancer: Results from cancer and leukemia group B 89803. Cancer, 116(4), 957-966. https://doi.org/10.1002/cncr.24866
McCleary, Nadine Jackson ; Niedzwiecki, Donna ; Hollis, Donna ; Saltz, Leonard B. ; Schaefer, Paul ; Whittom, Renaud ; Hantel, Alexander ; Benson, Al ; Goldberg, Richard ; Meyerhardt, Jeffrey A. / Impact of smoking on patients with stage iii colon cancer : Results from cancer and leukemia group B 89803. In: Cancer. 2010 ; Vol. 116, No. 4. pp. 957-966.
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abstract = "BACKGROUND: Cigarette smoking has been shown to increase the risk of developing colorectal cancer, particularly smoking early in life. Little is known about the impact of tobacco use on colon cancer recurrence among colon cancer survivors. METHODS: The authors prospectively collected lifetime smoking history from stage III colon cancer patients enrolled in a phase 3 trial via self-report questionnaires during and 6 months after completion of adjuvant chemotherapy. Smoking status was defined as never, current, or past. Lifetime pack-years were defined as number of lifetime packs of cigarettes. Patients were followed for recurrence or death. RESULTS: Data on smoking history were captured on 1045 patients with stage III colon cancer receiving adjuvant therapy (46{\%} never smokers; 44{\%} past; 10{\%} current). The adjusted hazard ratio (HR) for disease-free survival (DFS) was 0.99 (95{\%} confidence interval [CI], 0.70-1.41), 1.17 (95{\%} CI 0.89-1.55), and 1.22 (95{\%} CI 0.92-1.61) for lifetime pack-years 0-10, 10-20, and 20+, respectively, compared with never smoking (P = .16). In a preplanned exploratory analysis of smoking intensity early in life, the adjusted HR for 12+ pack-years before age 30 years for DFS was 1.37 (95{\%} CI, 1.02-1.84) compared with never smoking (P = .04). The adjusted HR for DFS was 1.18 (95{\%} CI, 0.92-1.50) for past smokers and 1.10 (95{\%} CI, 0.73-1.64) for current smokers, compared with never smokers. CONCLUSIONS: Total tobacco usage early in life may be an important, independent prognostic factor of cancer recurrences and mortality in patients with stage III colon cancer.",
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McCleary, NJ, Niedzwiecki, D, Hollis, D, Saltz, LB, Schaefer, P, Whittom, R, Hantel, A, Benson, A, Goldberg, R & Meyerhardt, JA 2010, 'Impact of smoking on patients with stage iii colon cancer: Results from cancer and leukemia group B 89803', Cancer, vol. 116, no. 4, pp. 957-966. https://doi.org/10.1002/cncr.24866

Impact of smoking on patients with stage iii colon cancer : Results from cancer and leukemia group B 89803. / McCleary, Nadine Jackson; Niedzwiecki, Donna; Hollis, Donna; Saltz, Leonard B.; Schaefer, Paul; Whittom, Renaud; Hantel, Alexander; Benson, Al; Goldberg, Richard; Meyerhardt, Jeffrey A.

In: Cancer, Vol. 116, No. 4, 15.02.2010, p. 957-966.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Impact of smoking on patients with stage iii colon cancer

T2 - Results from cancer and leukemia group B 89803

AU - McCleary, Nadine Jackson

AU - Niedzwiecki, Donna

AU - Hollis, Donna

AU - Saltz, Leonard B.

AU - Schaefer, Paul

AU - Whittom, Renaud

AU - Hantel, Alexander

AU - Benson, Al

AU - Goldberg, Richard

AU - Meyerhardt, Jeffrey A.

PY - 2010/2/15

Y1 - 2010/2/15

N2 - BACKGROUND: Cigarette smoking has been shown to increase the risk of developing colorectal cancer, particularly smoking early in life. Little is known about the impact of tobacco use on colon cancer recurrence among colon cancer survivors. METHODS: The authors prospectively collected lifetime smoking history from stage III colon cancer patients enrolled in a phase 3 trial via self-report questionnaires during and 6 months after completion of adjuvant chemotherapy. Smoking status was defined as never, current, or past. Lifetime pack-years were defined as number of lifetime packs of cigarettes. Patients were followed for recurrence or death. RESULTS: Data on smoking history were captured on 1045 patients with stage III colon cancer receiving adjuvant therapy (46% never smokers; 44% past; 10% current). The adjusted hazard ratio (HR) for disease-free survival (DFS) was 0.99 (95% confidence interval [CI], 0.70-1.41), 1.17 (95% CI 0.89-1.55), and 1.22 (95% CI 0.92-1.61) for lifetime pack-years 0-10, 10-20, and 20+, respectively, compared with never smoking (P = .16). In a preplanned exploratory analysis of smoking intensity early in life, the adjusted HR for 12+ pack-years before age 30 years for DFS was 1.37 (95% CI, 1.02-1.84) compared with never smoking (P = .04). The adjusted HR for DFS was 1.18 (95% CI, 0.92-1.50) for past smokers and 1.10 (95% CI, 0.73-1.64) for current smokers, compared with never smokers. CONCLUSIONS: Total tobacco usage early in life may be an important, independent prognostic factor of cancer recurrences and mortality in patients with stage III colon cancer.

AB - BACKGROUND: Cigarette smoking has been shown to increase the risk of developing colorectal cancer, particularly smoking early in life. Little is known about the impact of tobacco use on colon cancer recurrence among colon cancer survivors. METHODS: The authors prospectively collected lifetime smoking history from stage III colon cancer patients enrolled in a phase 3 trial via self-report questionnaires during and 6 months after completion of adjuvant chemotherapy. Smoking status was defined as never, current, or past. Lifetime pack-years were defined as number of lifetime packs of cigarettes. Patients were followed for recurrence or death. RESULTS: Data on smoking history were captured on 1045 patients with stage III colon cancer receiving adjuvant therapy (46% never smokers; 44% past; 10% current). The adjusted hazard ratio (HR) for disease-free survival (DFS) was 0.99 (95% confidence interval [CI], 0.70-1.41), 1.17 (95% CI 0.89-1.55), and 1.22 (95% CI 0.92-1.61) for lifetime pack-years 0-10, 10-20, and 20+, respectively, compared with never smoking (P = .16). In a preplanned exploratory analysis of smoking intensity early in life, the adjusted HR for 12+ pack-years before age 30 years for DFS was 1.37 (95% CI, 1.02-1.84) compared with never smoking (P = .04). The adjusted HR for DFS was 1.18 (95% CI, 0.92-1.50) for past smokers and 1.10 (95% CI, 0.73-1.64) for current smokers, compared with never smokers. CONCLUSIONS: Total tobacco usage early in life may be an important, independent prognostic factor of cancer recurrences and mortality in patients with stage III colon cancer.

KW - Adjuvant chemotherapy

KW - Cancer recurrence

KW - Cancer survival

KW - Colorectal cancer

KW - Smoking

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McCleary NJ, Niedzwiecki D, Hollis D, Saltz LB, Schaefer P, Whittom R et al. Impact of smoking on patients with stage iii colon cancer: Results from cancer and leukemia group B 89803. Cancer. 2010 Feb 15;116(4):957-966. https://doi.org/10.1002/cncr.24866