Impact of subclinical hypothyroidism in women with recurrent early pregnancy loss

Lia A. Bernardi, Ronald N. Cohen, Mary D. Stephenson*

*Corresponding author for this work

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

Objective To assess the impact of subclinical hypothyroidism (SCH) in women with recurrent early pregnancy loss (REPL). Design Observational cohort study. Setting REPL program in an academic medical center. Patient(s) 286 women with a history of ≥2 pregnancy losses <10 weeks. Intervention(s) From 2004-2007, no treatment for women with SCH (thyroid-stimulating hormone [TSH] >2.5 mIU/L with a normal free thyroxine or free thyroxine index); from 2008 onward, levothyroxine treatment prepregnancy to maintain TSH ≤2.5 mIU/L. Main Outcome Measure(s) Live-birth rate (LBR). Result(s) The prevalence of SCH was 55 (19%) of 286 in this REPL cohort. The cumulative LBR was 27 (69%) of 39 for women with SCH versus 104 (74%) of 141 for euthyroid women. The per-pregnancy LBR was 34 (49%) of 69 for SCH versus 129 (58%) of 221 for euthyroid women. When the LBR was compared between treated and untreated SCH, the cumulative LBR was 17 (71%) of 24 versus 10 (67%) of 15, respectively. The per-pregnancy LBR for SCH treated versus untreated women was 22 (48%) of 46 versus 12 (52%) of 23, respectively. Conclusion(s) Although there was a high prevalence of SCH in the REPL cohort, there was no statistically significant difference in the subsequent live-birth rate when comparing women with SCH and euthyroid women, or treated and untreated SCH.

Original languageEnglish (US)
Pages (from-to)1326-1331.e1
JournalFertility and Sterility
Volume100
Issue number5
DOIs
StatePublished - Nov 2013

Keywords

  • Euthyroid
  • pregnancy
  • recurrent miscarriage
  • recurrent pregnancy loss
  • subclinical hypothyroidism

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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