Impact of systemic treatment on local control for patients with lymph node-negative breast cancer treated with breast-conservation therapy

T. A. Buchholz*, S. L. Tucker, J. Erwin, D. Mathur, E. A. Strom, M. D. McNeese, G. N. Hortobagyi, M. Cristofanilli, F. J. Esteva, L. Newman, S. E. Singletary, A. U. Buzdar, K. K. Hunt

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

90 Scopus citations

Abstract

Purpose: To determine the impact of tamoxifen and chemotherapy on local control for breast cancer patients treated with breast-conservation therapy. Patients and Methods: The data from 484 breast cancer patients who were treated with breast-conserving surgery and radiation were analyzed. Only patients with lymph node-negative disease were studied to provide comparative groups with a similar stage of disease and a similar competing risk for distant metastases. Actuarial local control rates of the 277 patients treated with systemic therapy (128, chemotherapy with or without tamoxifen; 149, tamoxifen alone) were compared with the rates for the 207 patients who received no systemic treatment. Only 10% of the patients had positive (2%), close (3%), or unknown margin status (5%). Results: Patients treated with systemic therapy had improved 5-year (97.5% v 89.8%) and 8-year (95.6% v 85.2%) local control rates compared with those that did not receive systemic treatment (P = .004, log-rank test). There was no statistical difference in local control between patients treated with chemotherapy and patients treated with tamoxifen alone (P = .219). Systemic treatment, margin status, young patient age, estrogen and progesterone receptor status, and primary tumor size were analyzed in a Cox regression analysis. The use of systemic treatment was the most powerful predictor of local control: patients who did not receive systemic treatment had a relative risk of local recurrence of 3.3 (95% confidence interval, 1.5 to 7.5; P = .004). Conclusion: In this retrospective analysis, systemic therapy appears to contribute to long-term local control in patients with lymph node-negative breast cancer treated with breast-conservation therapy.

Original languageEnglish (US)
Pages (from-to)2240-2246
Number of pages7
JournalJournal of Clinical Oncology
Volume19
Issue number8
DOIs
StatePublished - Apr 15 2001

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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