Impact of systems biology on metabolic engineering of Saccharomyces cerevisiae

Jens Nielsen*, Michael C. Jewett

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

100 Scopus citations

Abstract

Industrial biotechnology is a rapidly growing field. With the increasing shift towards a bio-based economy, there is rising demand for developing efficient cell factories that can produce fuels, chemicals, pharmaceuticals, materials, nutraceuticals, and even food ingredients. The yeast Saccharomyces cerevisiae is extremely well suited for this objective. As one of the most intensely studied eukaryotic model organisms, a rich density of knowledge detailing its genetics, biochemistry, physiology, and large-scale fermentation performance can be capitalized upon to enable a substantial increase in the industrial application of this yeast. Developments in genomics and high-throughput systems biology tools are enhancing one's ability to rapidly characterize cellular behaviour, which is valuable in the field of metabolic engineering where strain characterization is often the bottleneck in strain development programmes. Here, the impact of systems biology on metabolic engineering is reviewed and perspectives on the role of systems biology in the design of cell factories are given.

Original languageEnglish (US)
Pages (from-to)122-131
Number of pages10
JournalFEMS yeast research
Volume8
Issue number1
DOIs
StatePublished - Feb 2008

Keywords

  • Cell factory
  • Industrial biotechnology
  • Metabolic engineering
  • Model
  • Saccharomyces cerevisiae
  • Systems biology

ASJC Scopus subject areas

  • Microbiology
  • Applied Microbiology and Biotechnology

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