Impact of the bacterial type I cytochrome c maturation system on different biological processes

Nicholas P Cianciotto*, Pierre Cornelis, Christine Baysse

*Corresponding author for this work

Research output: Contribution to journalShort survey

39 Citations (Scopus)

Abstract

In the α-, β- and γ-Proteobacteria, the so-called cytochrome c maturation (Ccm) system is known to promote the covalent attachment of the haem to periplasmic apocytochrome c. However, in species of Pseudomonas, Rhizobium, Paracoccus and Legionella, mutations in com genes result in phenotypes that cannot be readily explained by the simple loss of a c-type cytochrome. These phenotypes include loss of siderophore production and utilization, reduced abilities to grow in low-iron conditions and in mammalian and protozoan host cells, and alterations in copper sensitivity and manganese oxidation. These various data suggest that Ccm proteins may perform one or more functions in addition to Ccm, which are critical for bacterial physiology and growth. Novel hypotheses that should be explored include the utilization of Ccm-associated haem for processes besides attachment to apocytochrome c, the export of a non-haem compound through the Ccm system, and the negative effects of protoporphyrin IX accumulation.

Original languageEnglish (US)
Pages (from-to)1408-1415
Number of pages8
JournalMolecular Microbiology
Volume56
Issue number6
DOIs
StatePublished - Jun 1 2005

Fingerprint

Cytochrome c Group
Biological Phenomena
Cytochromes c
Heme
Paracoccus
Bacterial Physiological Phenomena
Phenotype
Siderophores
Proteobacteria
Legionella
Rhizobium
Manganese
Pseudomonas
Copper
Iron
Mutation
Growth
Genes
Proteins

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

Cite this

@article{35cc430fc7f94a1db0e1f0ae9ec2ce79,
title = "Impact of the bacterial type I cytochrome c maturation system on different biological processes",
abstract = "In the α-, β- and γ-Proteobacteria, the so-called cytochrome c maturation (Ccm) system is known to promote the covalent attachment of the haem to periplasmic apocytochrome c. However, in species of Pseudomonas, Rhizobium, Paracoccus and Legionella, mutations in com genes result in phenotypes that cannot be readily explained by the simple loss of a c-type cytochrome. These phenotypes include loss of siderophore production and utilization, reduced abilities to grow in low-iron conditions and in mammalian and protozoan host cells, and alterations in copper sensitivity and manganese oxidation. These various data suggest that Ccm proteins may perform one or more functions in addition to Ccm, which are critical for bacterial physiology and growth. Novel hypotheses that should be explored include the utilization of Ccm-associated haem for processes besides attachment to apocytochrome c, the export of a non-haem compound through the Ccm system, and the negative effects of protoporphyrin IX accumulation.",
author = "Cianciotto, {Nicholas P} and Pierre Cornelis and Christine Baysse",
year = "2005",
month = "6",
day = "1",
doi = "10.1111/j.1365-2958.2005.04650.x",
language = "English (US)",
volume = "56",
pages = "1408--1415",
journal = "Molecular Microbiology",
issn = "0950-382X",
publisher = "Wiley-Blackwell",
number = "6",

}

Impact of the bacterial type I cytochrome c maturation system on different biological processes. / Cianciotto, Nicholas P; Cornelis, Pierre; Baysse, Christine.

In: Molecular Microbiology, Vol. 56, No. 6, 01.06.2005, p. 1408-1415.

Research output: Contribution to journalShort survey

TY - JOUR

T1 - Impact of the bacterial type I cytochrome c maturation system on different biological processes

AU - Cianciotto, Nicholas P

AU - Cornelis, Pierre

AU - Baysse, Christine

PY - 2005/6/1

Y1 - 2005/6/1

N2 - In the α-, β- and γ-Proteobacteria, the so-called cytochrome c maturation (Ccm) system is known to promote the covalent attachment of the haem to periplasmic apocytochrome c. However, in species of Pseudomonas, Rhizobium, Paracoccus and Legionella, mutations in com genes result in phenotypes that cannot be readily explained by the simple loss of a c-type cytochrome. These phenotypes include loss of siderophore production and utilization, reduced abilities to grow in low-iron conditions and in mammalian and protozoan host cells, and alterations in copper sensitivity and manganese oxidation. These various data suggest that Ccm proteins may perform one or more functions in addition to Ccm, which are critical for bacterial physiology and growth. Novel hypotheses that should be explored include the utilization of Ccm-associated haem for processes besides attachment to apocytochrome c, the export of a non-haem compound through the Ccm system, and the negative effects of protoporphyrin IX accumulation.

AB - In the α-, β- and γ-Proteobacteria, the so-called cytochrome c maturation (Ccm) system is known to promote the covalent attachment of the haem to periplasmic apocytochrome c. However, in species of Pseudomonas, Rhizobium, Paracoccus and Legionella, mutations in com genes result in phenotypes that cannot be readily explained by the simple loss of a c-type cytochrome. These phenotypes include loss of siderophore production and utilization, reduced abilities to grow in low-iron conditions and in mammalian and protozoan host cells, and alterations in copper sensitivity and manganese oxidation. These various data suggest that Ccm proteins may perform one or more functions in addition to Ccm, which are critical for bacterial physiology and growth. Novel hypotheses that should be explored include the utilization of Ccm-associated haem for processes besides attachment to apocytochrome c, the export of a non-haem compound through the Ccm system, and the negative effects of protoporphyrin IX accumulation.

UR - http://www.scopus.com/inward/record.url?scp=20344383510&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=20344383510&partnerID=8YFLogxK

U2 - 10.1111/j.1365-2958.2005.04650.x

DO - 10.1111/j.1365-2958.2005.04650.x

M3 - Short survey

VL - 56

SP - 1408

EP - 1415

JO - Molecular Microbiology

JF - Molecular Microbiology

SN - 0950-382X

IS - 6

ER -