Impact of the bacterial type I cytochrome c maturation system on different biological processes

Nicholas P. Cianciotto*, Pierre Cornelis, Christine Baysse

*Corresponding author for this work

Research output: Contribution to journalShort survey

40 Scopus citations

Abstract

In the α-, β- and γ-Proteobacteria, the so-called cytochrome c maturation (Ccm) system is known to promote the covalent attachment of the haem to periplasmic apocytochrome c. However, in species of Pseudomonas, Rhizobium, Paracoccus and Legionella, mutations in com genes result in phenotypes that cannot be readily explained by the simple loss of a c-type cytochrome. These phenotypes include loss of siderophore production and utilization, reduced abilities to grow in low-iron conditions and in mammalian and protozoan host cells, and alterations in copper sensitivity and manganese oxidation. These various data suggest that Ccm proteins may perform one or more functions in addition to Ccm, which are critical for bacterial physiology and growth. Novel hypotheses that should be explored include the utilization of Ccm-associated haem for processes besides attachment to apocytochrome c, the export of a non-haem compound through the Ccm system, and the negative effects of protoporphyrin IX accumulation.

Original languageEnglish (US)
Pages (from-to)1408-1415
Number of pages8
JournalMolecular Microbiology
Volume56
Issue number6
DOIs
StatePublished - Jun 1 2005

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

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