Impact of traumatic brain injury on amyotrophic lateral sclerosis: From bedside to bench

Colin K. Franz, Divya Joshi, Elizabeth L. Daley, Rogan A. Grant, Kyriakos Dalamagkas, Audrey Leung, John D. Finan, Evangelos Kiskinis*

*Corresponding author for this work

Research output: Contribution to journalReview article

2 Scopus citations

Abstract

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the loss of upper and lower motor neurons, which manifests clinically as progressive weakness. Although several epidemiological studies have found an association between traumatic brain injury (TBI) and ALS, there is not a consensus on whether TBI is an ALS risk factor. It may be that it can cause ALS in a subset of susceptible patients, based on a history of repetitive mild TBI and genetic predisposition. This cannot be determined based on clinical observational studies alone. Better preclinical models are necessary to evaluate the effects of TBI on ALS onset and progression. To date, only a small number of preclinical studies have been performed, mainly in the superoxide dismutase 1 transgenic rodents, which, taken together, have mixed results and notable methodological limitations. The more recent incorporation of additional animal models such as Drosophila flies, as well as patient-induced pluripotent stem cell-derived neurons, should facilitate a better understanding of a potential functional interaction between TBI and ALS.

Original languageEnglish (US)
Pages (from-to)1174-1185
Number of pages12
JournalJournal of neurophysiology
Volume122
Issue number3
DOIs
StatePublished - Jan 1 2019

Keywords

  • Amyotrophic lateral sclerosis (ALS)
  • Concussion
  • Induced pluripotent stem cell (iPSC)
  • Superoxide dismutase 1 (SOD1)
  • TAR DNA-binding protein 43 (TDP-43)
  • Traumatic brain injury (TBI)

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology

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