TY - JOUR
T1 - Impact of Weight on Ventricular Assist Device Outcomes in Dilated Cardiomyopathy Patients in Pediatric Centers
T2 - An ACTION Registry Study
AU - ACTION Network Investigators
AU - Kwiatkowski, David M.
AU - Shezad, Muhammad
AU - Barnes, Aliessa P.
AU - Ploutz, Michelle S.
AU - Law, Sabrina P.
AU - Zafar, Farhan
AU - Morales, David L.S.
AU - O'Connor, Matthew J.
AU - Ahmed, Humera
AU - Aljohani, Othman A.
AU - Auerbach, Scott R.
AU - Bansal, Neha
AU - Bearl, David W.
AU - Brickler, Molly
AU - Buchholz, Holger
AU - Byrnes, Jonathan W.
AU - Carrington, Sydney
AU - Chandnani, Harsha K.
AU - Conway, Jennifer L.
AU - Do, Nhue L.
AU - Dykes, John C.
AU - Honjo, Osami
AU - Jeewa, Aamir
AU - Joong, Anna
AU - Kindel, Steven J.
AU - Kleinmahon, Jake A.
AU - Lantz, Jodie
AU - Lorts, Angela
AU - Maeda, Katsuhide
AU - Mao, Chad Y.
AU - Mauchley, David C.
AU - May, Lindsay
AU - Mccormick, Amanda D.
AU - Nandi, Deipanjan
AU - Peng, David M.
AU - Rosenthal, David N.
AU - Shugh, Svetlana
AU - Simpson, Kathleen E.
AU - Watanbe, Kae
AU - Wilkens, Sarah J.
AU - Wright, Lydia K.
AU - Zinn, Matthew D.
N1 - Publisher Copyright:
© 2023 Lippincott Williams and Wilkins. All rights reserved.
PY - 2023/5/1
Y1 - 2023/5/1
N2 - Ventricular assist device (VAD) options vary for children in different weight groups. This study evaluates contemporary device usage and outcomes for children based on weight. Data from the Advanced Cardiac Therapies Improving Outcomes Network (ACTION) registry were examined for patients with dilated cardiomyopathy (DCM) in 4 weight cohorts: <8 kg, 8-20 kg, 21-40 kg, and >40 kg, for devices implanted 3/2013-10/2020. Adverse event rates and ultimate outcome (deceased, alive on device, transplanted, or ventricular recovery) were analyzed. 222 DCM patients were identified with 24% in cohort 1, 23% in cohort 2, 15% in cohort 3, and 38% in cohort 4. Of 272 total implants, paracorporeal pulsatile devices were most common (95%) in cohorts 1 and 2 and intracorporeal continuous devices (81%) in cohorts 3 and 4. Stroke was noted in 17%, 12%, 6%, and 4% of cohorts, respectively (Cohort 1 vs. 4 and 2 vs. 4 - p = 0.01; other comparisons - not significant). Incidences of major bleeding, device malfunction, and infection was not different. All cohorts had >90% positive outcomes. Stroke incidence was higher in smaller cohorts, but other outcomes were similar. Positive outcomes were attained in over 90% across all weight groups, demonstrating excellent outcomes using current VADs in this DCM population.
AB - Ventricular assist device (VAD) options vary for children in different weight groups. This study evaluates contemporary device usage and outcomes for children based on weight. Data from the Advanced Cardiac Therapies Improving Outcomes Network (ACTION) registry were examined for patients with dilated cardiomyopathy (DCM) in 4 weight cohorts: <8 kg, 8-20 kg, 21-40 kg, and >40 kg, for devices implanted 3/2013-10/2020. Adverse event rates and ultimate outcome (deceased, alive on device, transplanted, or ventricular recovery) were analyzed. 222 DCM patients were identified with 24% in cohort 1, 23% in cohort 2, 15% in cohort 3, and 38% in cohort 4. Of 272 total implants, paracorporeal pulsatile devices were most common (95%) in cohorts 1 and 2 and intracorporeal continuous devices (81%) in cohorts 3 and 4. Stroke was noted in 17%, 12%, 6%, and 4% of cohorts, respectively (Cohort 1 vs. 4 and 2 vs. 4 - p = 0.01; other comparisons - not significant). Incidences of major bleeding, device malfunction, and infection was not different. All cohorts had >90% positive outcomes. Stroke incidence was higher in smaller cohorts, but other outcomes were similar. Positive outcomes were attained in over 90% across all weight groups, demonstrating excellent outcomes using current VADs in this DCM population.
KW - VAD
KW - dilated cardiomyopathy
KW - pediatric VAD
KW - pediatric ventricular assist device
KW - ventricular assist device
UR - http://www.scopus.com/inward/record.url?scp=85158827890&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85158827890&partnerID=8YFLogxK
U2 - 10.1097/MAT.0000000000001861
DO - 10.1097/MAT.0000000000001861
M3 - Article
C2 - 37071761
AN - SCOPUS:85158827890
SN - 1058-2916
VL - 69
SP - 496
EP - 503
JO - ASAIO Journal
JF - ASAIO Journal
IS - 5
ER -