Impaired acquisition and rapid forgetting of patterned visual stimuli in Alzheimer's disease

Bruce R. Reed*, Ken Paller, Dan Mungas

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Whether or not rate of forgetting is accelerated in Alzheimer's disease (AD) is controversial. This study examined recognition of visual patterns in patients with AD and in controls at 10 min relative to a learning baseline measured after a 10-s delay (delayed recognition ratio, DRR). Comparable baseline performances were attained in the two groups by manipulating stimulus exposure times. Comparisons between 25 AD and 48 age-matched controls demonstrated lower DRR in AD when initial recognition, which was statistically worse in AD, was covariated. DRR was also lower in an analysis of subgroups closely matched on initial performance. The findings suggest that forgetting is accelerated in AD because multiple aspects of memory processing, including storage, are impaired.

Original languageEnglish (US)
Pages (from-to)738-749
Number of pages12
JournalJournal of Clinical and Experimental Neuropsychology
Volume20
Issue number5
DOIs
StatePublished - Jan 1 1998

ASJC Scopus subject areas

  • Clinical Psychology
  • Neurology
  • Clinical Neurology

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