Impaired Insight in Alzheimer's Disease

Carlos A. Mangone; Ronald J. Ganellen; Regina Boarman; Winifred C. Dollear; Daniel B. Hier; Philip B. Gorelick; Patricia Langenberg

doi:10.1177/089198879100400402

Impaired Insight in Alzheimer's Disease

Carlos A. Mangone, Ronald J. Ganellen, Regina Boarman, Winifred C. Dollear, Daniel B. Hier^*, Philip B. Gorelick, Patricia Langenberg

^*Corresponding author for this work

Neurology

Research output: Contribution to journal › Article › peer-review

134 Scopus citations

Abstract

We studied insight into illness in 41 patients with probable Alzheimer's disease. An impaired insight score was developed by measuring discrepancies between patient report and caregiver report on standard instruments of activities of daily living. Insight was more impaired in subjects with greater dementia severity and subjects with paranoid delusions. In a multivariate analysis, the best neuropsychological predictors of impaired insight were the Continuous Performance Test and the Visual Reproduction Test. We speculate that the impaired insight of Alzheimer's disease has two components: confabulation reflecting prefrontal dysfunction and anosognosia reflecting right-hemisphere dysfunction. (J Geriatr Psychiatry Neurol 1991;4:189-193).

Original language	English (US)
Pages (from-to)	189-193
Number of pages	5
Journal	Journal of Geriatric Psychiatry and Neurology
Volume	4
Issue number	4
DOIs	https://doi.org/10.1177/089198879100400402
State	Published - Oct 1991

ASJC Scopus subject areas

Clinical Neurology
Geriatrics and Gerontology
Psychiatry and Mental health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1177/089198879100400402

Cite this

@article{e6042dd4f6604ff0ab7de6f533c398f0,

title = "Impaired Insight in Alzheimer's Disease",

abstract = "We studied insight into illness in 41 patients with probable Alzheimer's disease. An impaired insight score was developed by measuring discrepancies between patient report and caregiver report on standard instruments of activities of daily living. Insight was more impaired in subjects with greater dementia severity and subjects with paranoid delusions. In a multivariate analysis, the best neuropsychological predictors of impaired insight were the Continuous Performance Test and the Visual Reproduction Test. We speculate that the impaired insight of Alzheimer's disease has two components: confabulation reflecting prefrontal dysfunction and anosognosia reflecting right-hemisphere dysfunction. (J Geriatr Psychiatry Neurol 1991;4:189-193).",

author = "Mangone, {Carlos A.} and Ganellen, {Ronald J.} and Regina Boarman and Dollear, {Winifred C.} and Hier, {Daniel B.} and Gorelick, {Philip B.} and Patricia Langenberg",

year = "1991",

month = oct,

doi = "10.1177/089198879100400402",

language = "English (US)",

volume = "4",

pages = "189--193",

journal = "Journal of Geriatric Psychiatry and Neurology",

issn = "0891-9887",

publisher = "SAGE Publications Inc.",

number = "4",

}

TY - JOUR

T1 - Impaired Insight in Alzheimer's Disease

AU - Mangone, Carlos A.

AU - Ganellen, Ronald J.

AU - Boarman, Regina

AU - Dollear, Winifred C.

AU - Hier, Daniel B.

AU - Gorelick, Philip B.

AU - Langenberg, Patricia

PY - 1991/10

Y1 - 1991/10

N2 - We studied insight into illness in 41 patients with probable Alzheimer's disease. An impaired insight score was developed by measuring discrepancies between patient report and caregiver report on standard instruments of activities of daily living. Insight was more impaired in subjects with greater dementia severity and subjects with paranoid delusions. In a multivariate analysis, the best neuropsychological predictors of impaired insight were the Continuous Performance Test and the Visual Reproduction Test. We speculate that the impaired insight of Alzheimer's disease has two components: confabulation reflecting prefrontal dysfunction and anosognosia reflecting right-hemisphere dysfunction. (J Geriatr Psychiatry Neurol 1991;4:189-193).

AB - We studied insight into illness in 41 patients with probable Alzheimer's disease. An impaired insight score was developed by measuring discrepancies between patient report and caregiver report on standard instruments of activities of daily living. Insight was more impaired in subjects with greater dementia severity and subjects with paranoid delusions. In a multivariate analysis, the best neuropsychological predictors of impaired insight were the Continuous Performance Test and the Visual Reproduction Test. We speculate that the impaired insight of Alzheimer's disease has two components: confabulation reflecting prefrontal dysfunction and anosognosia reflecting right-hemisphere dysfunction. (J Geriatr Psychiatry Neurol 1991;4:189-193).

UR - http://www.scopus.com/inward/record.url?scp=0026344482&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026344482&partnerID=8YFLogxK

U2 - 10.1177/089198879100400402

DO - 10.1177/089198879100400402

M3 - Article

C2 - 1789906

AN - SCOPUS:0026344482

SN - 0891-9887

VL - 4

SP - 189

EP - 193

JO - Journal of Geriatric Psychiatry and Neurology

JF - Journal of Geriatric Psychiatry and Neurology

IS - 4

ER -

Impaired Insight in Alzheimer's Disease

Abstract

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this