Impaired insulin sensitivity is associated with worsening cognition in HIV-infected patients

Saja S. Khuder, Suming Chen, Scott Letendre, Thomas Marcotte, Igor Grant, Donald Franklin, Leah H. Rubin, Joseph B. Margolick, Lisa P. Jacobson, Ned Sacktor, Gypsyamber D'souza, Valentina Stosor, Jordan E. Lake, Giovanna Rapocciolo, Justin C. Mcarthur, Alex M. Dickens, Norman J. Haughey*

*Corresponding author for this work

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

ObjectiveTo determine the association of insulin sensitivity and metabolic status with declining cognition in HIV-infected individuals.MethodsWe conducted targeted clinical and metabolic measures in longitudinal plasma samples obtained from HIV-infected patients enrolled in the Central Nervous System HIV Anti-Retroviral Therapy Effects Research Study (CHARTER). Findings were validated with plasma samples from the Multicenter AIDS Cohort Study (MACS). Patients were grouped according to longitudinally and serially assessed cognitive performance as having stably normal or declining cognition.ResultsPatients with declining cognition exhibited baseline hyperinsulinemia and elevated plasma c-peptide levels with normal c-peptide/insulin ratios, suggesting that insulin production was increased, but insulin clearance was normal. The association of hyperinsulinemia with worsening cognition was further supported by low high-density lipoprotein (HDL), high low-density lipoprotein/HDL ratio, and elevated cholesterol/HDL ratio compared to patients with stably normal cognition.ConclusionsThese findings suggest that hyperinsulinemia and impaired insulin sensitivity are associated with cognitive decline in antiretroviral therapy-treated HIV-infected patients.

Original languageEnglish (US)
Pages (from-to)E1344-E1353
JournalNeurology
Volume92
Issue number12
DOIs
StatePublished - Mar 19 2019

    Fingerprint

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Khuder, S. S., Chen, S., Letendre, S., Marcotte, T., Grant, I., Franklin, D., Rubin, L. H., Margolick, J. B., Jacobson, L. P., Sacktor, N., D'souza, G., Stosor, V., Lake, J. E., Rapocciolo, G., Mcarthur, J. C., Dickens, A. M., & Haughey, N. J. (2019). Impaired insulin sensitivity is associated with worsening cognition in HIV-infected patients. Neurology, 92(12), E1344-E1353. https://doi.org/10.1212/WNL.0000000000007125