Impaired left ventricular diastolic filling in patients with coronary artery disease: Assessment with radionuclide angiography

R. O. Bonow, S. L. Bacharach, M. V. Green, K. M. Kent, D. R. Rosing, L. C. Lipson, M. B. Leon, S. E. Epstein

Research output: Contribution to journalArticle

489 Scopus citations

Abstract

To assess left ventricular (LV) diastolic filling at rest in patients with coronary artery disease (CAD), we analyzed high-resolution time-activity curves (10-20 msec/frame) obtained from gated radionuclide angiograms in 231 patients. Peak LV filling rate (PFR), expressed in end-diastolic volumes per second (EDV/sec), was subnormal in CAD patients (1.8 ± 0.6 [±SD) vs normal mean of 3.3 ± 0.6, p < 0.001) and time to PFR (TPFR), measured from end-systole to PFR, was prolonged (171 ± 41 msec vs normal mean of 136 ± 23 msec, p < 0.001). These indexes were also abnormal in the 141 patients with normal resting LV ejection fraction (PFR = 2.1 ± 0.5 EDV/sec; TPFR = 175 ± 36 msec) and in 123 patients without Q waves on the ECG (PFR = 2.1 ± 0.5 EDV/sec; TPFR = 168 ± 38 msec). Abnormal LV filling at rest (PFR < 2.5 EDV/sec or TPFR > 180 msec) was found in 91% of all patients with CAD, 86% of patients with normal resting LV ejection fractions, 85% of patients without Q waves, and 82% of patients with normal resting LV ejection fraction, no resting regional wall motion abnormalities and no Q waves. Thus, LV diastolic filling, evaluated noninvasively by radionuclide angiography, is abnormal in a high percentage of patients with CAD at rest independent of LV systolic function or previous myocardial infarction.

Original languageEnglish (US)
Pages (from-to)315-323
Number of pages9
JournalUnknown Journal
Volume64
Issue number2
DOIs
StatePublished - Jan 1 1981

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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    Bonow, R. O., Bacharach, S. L., Green, M. V., Kent, K. M., Rosing, D. R., Lipson, L. C., Leon, M. B., & Epstein, S. E. (1981). Impaired left ventricular diastolic filling in patients with coronary artery disease: Assessment with radionuclide angiography. Unknown Journal, 64(2), 315-323. https://doi.org/10.1161/01.CIR.64.2.315