Impaired NK1+ T cell development and early IL-4 production in CD1-deficient mice

Yi Hua Chen*, Nancy M. Chiu, Manas Mandal, Ning Wang, Chyung Ru Wang

*Corresponding author for this work

Research output: Contribution to journalArticle

410 Scopus citations

Abstract

The MHG class Ib molecule, CD1, has been conserved throughout mammalian evolution. To assess the function of CD1 in lymphocyte development, we generated mice with targeted disruption of the CD1.1 CD1.2 genes. CD1-deficient mice have normal numbers of CD4+ and CD8+ T cells but marked reduction in NK1.1 bearing T cells, particularly those with a canonical gene rearrangement of Vαy14-Jα281. CD1-deficient mice are unable to generate a rapid IL-4 response following systemic T cell activation but can generate effective antigen-specific Th2 responses. Thus, CD1 is required for the development of a specialized subset of T lymphocytes with a monomorphic antigen receptor. The rapid effector cytokine secretion of these T cells suggests that CD1 educates adaptive immune cells to subserve functions of innate immunity.

Original languageEnglish (US)
Pages (from-to)459-467
Number of pages9
JournalImmunity
Volume6
Issue number4
DOIs
StatePublished - Apr 1 1997

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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