Impaired post-transcriptional regulation in Alzheimer's disease

Li Zhu*, Jiang Hong Liu, Jane Wu

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

Post-transcriptional regulation plays a central role in the development and maintenance of the nervous system. Defects in post-transcriptional regulation lead to neurodegenerative diseases. Mounting evidence suggests that the impaired post-transcriptional regulation of associated genes contribute to the neurodegenerative process, such as Alzheimer's disease (AD). This review discusses the role of disruption of alternative splicing regulation of the human tau gene (MAPT) and alterations of microRNA expression in the pathogenesis of neurodegeneration including AD. A brief overview is provided for the role and the mechanism of post-transcriptional regulation in AD pathogenesis.

Original languageEnglish (US)
Pages (from-to)703-708
Number of pages6
JournalProgress in Biochemistry and Biophysics
Volume39
Issue number8
DOIs
StatePublished - Aug 1 2012

Keywords

  • Alzhemer's disease
  • Non-coding RNAs (ncRNAs)
  • Post-transcriptional regulation
  • RNA binding proteins (RBPs)
  • RNA spicing

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry

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