Impaired prostate tumorigenesis in Egr1-deficient mice

Sarki A. Abdulkadir, Zhican Qu, Emily Garabedian, Sheng Kwei Song, Thomas J. Peters, John Svaren, Joseph M. Carbone, Cathy K. Naughton, William J. Catalona, Joseph J H Ackerman, Jeffrey I. Gordon, Peter A. Humphrey, Jeffrey Milbrandt*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

152 Scopus citations

Abstract

The transcription factor, early growth response protein 1 (EGR1), is overexpressed in a majority of human prostate cancers and is implicated in the regulation of several genes important for prostate tumor progression. Here we have assessed the effect of Egr1 deficiency on tumor development in two transgenic mouse models of prostate cancer (CR2-T-Ag and TRAMP). Using a combination of high-resolution magnetic resonance imaging and histopathological and survival analyses, we show that tumor progression was significantly impaired in Egr1 -1- mice. Tumor initiation and tumor growth rate were not affected by the lack of Egr1; however, Egr1 deficiency significantly delayed the progression from prostatic intra-epithelial neoplasia to invasive carcinoma. These results indicate a unique role for Egr1 in regulating the transition from localized, carcinoma in situ to invasive carcinoma.

Original languageEnglish (US)
Pages (from-to)101-107
Number of pages7
JournalNature Medicine
Volume7
Issue number1
DOIs
StatePublished - 2001

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'Impaired prostate tumorigenesis in Egr1-deficient mice'. Together they form a unique fingerprint.

Cite this