Impaired trace eyeblink conditioning in bilateral, medial-temporal lobe amnesia

Regina McGlinchey-Berroth*, John D E Gabrieli, Maria C. Carrillo, Catherine M. Brawn, John F. Disterhoft

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

159 Scopus citations


Trace eyeblink classical conditioning was assessed in patients with bilateral medial-temporal amnesia and matched control participants who had previously shown equivalent delay eyeblink conditioning (J. D. E. Gabrieli et al., 1995). The silent trace interval varied for durations of 500, 750, or 1,000 ms in successive sessions separated by at least 2 weeks; extinction trials followed each session. Patients with amnesia produced significantly fewer conditioned responses (CRs) than did control participants at all trace intervals. Both groups produced fewer CRs as the trace interval lengthened. Thus, the temporal lobe memory system in humans makes an essential contribution to normal acquisition in trace, but not delay, classical eyeblink conditioning.

Original languageEnglish (US)
Pages (from-to)873-882
Number of pages10
JournalBehavioral Neuroscience
Issue number5
StatePublished - 1997

ASJC Scopus subject areas

  • Behavioral Neuroscience


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