Impairment of axonal development and of synaptogenesis in hippocampal neurons of synapsin I-deficient mice

Lih Shen Chin, Lian Li*, Adriana Ferreira, Kenneth S. Kosik, Paul Greengard

*Corresponding author for this work

Research output: Contribution to journalArticle

207 Scopus citations

Abstract

Synapsin I, the most abundant of all neuronal phosphoproteins, is enriched in synaptic vesicles. It has been hypothesized to regulate synaptogenesis and neurotransmitter release from adult nerve terminals. The evidence for such roles has been highly suggestive but not compelling. To evaluate the possible involvement of synapsin I in synaptogenesis and in the function of adult synapses, we have generated synapsin I-deficient mice by homologous recombination. We report herein that outgrowth of predendritic neurites and of axons was severely retarded in the hippocampal neurons of embryonic synapsin I mutant mice. Furthermore, synapse formation was significantly delayed in these mutant neurons. These results indicate that synapsin I plays a role in regulation of axonogenesis and synaptogenesis.

Original languageEnglish (US)
Pages (from-to)9230-9234
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume92
Issue number20
DOIs
StatePublished - Sep 26 1995

ASJC Scopus subject areas

  • Genetics
  • General

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