Implantation and control of wireless, battery-free systems for peripheral nerve interfacing

Hongkai Wang; Dom D’andrea; Yeon Sik Choi; Yasmine Bouricha; Grace Wickerson; Hak Young Ahn; Hexia Guo; Yonggang Huang; Milap S. Sandhu; Sumanas W. Jordan; John A. Rogers; Colin K. Franz

doi:10.3791/63085

Implantation and control of wireless, battery-free systems for peripheral nerve interfacing

Hongkai Wang, Dom D’andrea, Yeon Sik Choi, Yasmine Bouricha, Grace Wickerson, Hak Young Ahn, Hexia Guo, Yonggang Huang, Milap S. Sandhu, Sumanas W. Jordan, John A. Rogers, Colin K. Franz^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Peripheral nerve interfaces are frequently used in experimental neuroscience and regenerative medicine for a wide variety of applications. Such interfaces can be sensors, actuators, or both. Traditional methods of peripheral nerve interfacing must either tether to an external system or rely on battery power that limits the time frame for operation. With recent developments of wireless, battery-free, and fully implantable peripheral nerve interfaces, a new class of devices can offer capabilities that match or exceed those of their wired or battery-powered precursors. This paper describes methods to (i) surgically implant and (ii) wirelessly power and control this system in adult rats. The sciatic and phrenic nerve models were selected as examples to highlight the versatility of this approach. The paper shows how the peripheral nerve interface can evoke compound muscle action potentials (CMAPs), deliver a therapeutic electrical stimulation protocol, and incorporate a conduit for the repair of peripheral nerve injury. Such devices offer expanded treatment options for single-dose or repeated dose therapeutic stimulation and can be adapted to a variety of nerve locations.

Original language	English (US)
Article number	e63085
Journal	Journal of Visualized Experiments
Issue number	176
DOIs	https://doi.org/10.3791/63085
State	Published - Oct 2021

Funding

This work used the NUFAB facility of Northwestern University's NUANCE Center, which has received support from the SHyNE Resource (NSF ECCS-1542205), the IIN, and Northwestern's MRSEC program (NSF DMR-1720139). This work made use of the MatCI Facility supported by the MRSEC program of the National Science Foundation (DMR-1720139) at the Materials Research Center of Northwestern University. C.K.F acknowledges support from Eunice Kennedy Shriver Institute of Child Health and Human Development of the NIH (grant no. R03HD101090) and the American Neuromuscular Foundation (Development Grant). Y.H. acknowledges support from NSF (grant no. CMMI1635443). This work was supported by the Querrey Simpson Institute for Bioelectronics at Northwestern University.

ASJC Scopus subject areas

General Neuroscience
General Chemical Engineering
General Biochemistry, Genetics and Molecular Biology
General Immunology and Microbiology

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title = "Implantation and control of wireless, battery-free systems for peripheral nerve interfacing",

abstract = "Peripheral nerve interfaces are frequently used in experimental neuroscience and regenerative medicine for a wide variety of applications. Such interfaces can be sensors, actuators, or both. Traditional methods of peripheral nerve interfacing must either tether to an external system or rely on battery power that limits the time frame for operation. With recent developments of wireless, battery-free, and fully implantable peripheral nerve interfaces, a new class of devices can offer capabilities that match or exceed those of their wired or battery-powered precursors. This paper describes methods to (i) surgically implant and (ii) wirelessly power and control this system in adult rats. The sciatic and phrenic nerve models were selected as examples to highlight the versatility of this approach. The paper shows how the peripheral nerve interface can evoke compound muscle action potentials (CMAPs), deliver a therapeutic electrical stimulation protocol, and incorporate a conduit for the repair of peripheral nerve injury. Such devices offer expanded treatment options for single-dose or repeated dose therapeutic stimulation and can be adapted to a variety of nerve locations.",

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AU - Wickerson, Grace

AU - Ahn, Hak Young

AU - Guo, Hexia

AU - Huang, Yonggang

AU - Sandhu, Milap S.

AU - Jordan, Sumanas W.

AU - Rogers, John A.

AU - Franz, Colin K.

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N2 - Peripheral nerve interfaces are frequently used in experimental neuroscience and regenerative medicine for a wide variety of applications. Such interfaces can be sensors, actuators, or both. Traditional methods of peripheral nerve interfacing must either tether to an external system or rely on battery power that limits the time frame for operation. With recent developments of wireless, battery-free, and fully implantable peripheral nerve interfaces, a new class of devices can offer capabilities that match or exceed those of their wired or battery-powered precursors. This paper describes methods to (i) surgically implant and (ii) wirelessly power and control this system in adult rats. The sciatic and phrenic nerve models were selected as examples to highlight the versatility of this approach. The paper shows how the peripheral nerve interface can evoke compound muscle action potentials (CMAPs), deliver a therapeutic electrical stimulation protocol, and incorporate a conduit for the repair of peripheral nerve injury. Such devices offer expanded treatment options for single-dose or repeated dose therapeutic stimulation and can be adapted to a variety of nerve locations.

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Implantation and control of wireless, battery-free systems for peripheral nerve interfacing

Abstract

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