Implementation of tuberculosis intensive case finding, isoniazid preventive therapy, and infection control ("Three I's") and HIV-tuberculosis service integration in lower income countries

M. Katherine Charles, Mary Lou Lindegren, C. William Wester, Meridith Blevins, Timothy R. Sterling, Nguyen Thi Dung, Jean Claude Dusingize, Divine Avit-Edi, Nicolas Durier, Barbara Castelnuovo, Gertrude Nakigozi, Claudia P. Cortes, Marie Ballif, Lukas Fenner, Samuel Ajayi, Kathryn Anastos, Jules Bashi, William Bishai, Andrew Boulle, Paula BraitsteinGabriela Carriquiry, Jane E. Carter, Peter Cegielski, Cleophas Chimbetete, Mary Ann Davies, Lameck Diero, Stephany Duda, Matthias Egger, Tanoh F. Eboua, Adrian Gasser, Elvin Geng, Joachim Charles Gnokori, Laura Hardwicke, Chris Hoffmann, Robin Huebner, Nzali Kancheya, Sasisopin Kiertiburanakul, Peter Kim, Diero Lameck, Valériane Leroy, Charlotte Lewden, Anna Mandalakas, Mhairi Maskew, Rosemary McKaig, Lynne Mofenson, Mireille Mpoudi-Etame, Benson Okwara, Sam Phiri, Wasana Prasitsuebsai, Firas Wehbe, International epidemiology Databases to Evaluate AIDS (IeDEA) Collaboration

    Research output: Contribution to journalArticle

    11 Citations (Scopus)

    Abstract

    Setting: World Health Organization advocates for integration of HIV-tuberculosis (TB) services and recommends intensive case finding (ICF), isoniazid preventive therapy (IPT), and infection control ("Three I's") for TB prevention and control among persons living with HIV. Objective: To assess the implementation of the "Three I's" of TB-control at HIV treatment sites in lower income countries. Design: Survey conducted between March-July, 2012 at 47 sites in 26 countries: 6 (13%) Asia Pacific, 7 (15%), Caribbean, Central and South America, 5 (10%) Central Africa, 8 (17%) East Africa, 14 (30%) Southern Africa, and 7 (15%) West Africa. Results: ICF using symptom-based screening was performed at 38% of sites; 45% of sites used symptom-screening plus additional diagnostics. IPT at enrollment or ART initiation was implemented in only 17% of sites, with 9% of sites providing IPT to tuberculin-skin-test positive patients. Infection control measures varied: 62% of sites separated smear-positive patients, and healthcare workers used masks at 57% of sites. Only 12 (26%) sites integrated HIV-TB services. Integration was not associated with implementation of TB prevention measures except for IPT provision at enrollment (42% integrated vs. 9% nonintegrated; p = 0.03). Conclusions: Implementation of TB screening, IPT provision, and infection control measures was low and variable across regional HIV treatment sites, regardless of integration status.

    Original languageEnglish (US)
    Article numbere0153243
    JournalPloS one
    Volume11
    Issue number4
    DOIs
    StatePublished - Apr 1 2016

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    isoniazid
    Isoniazid
    Infection Control
    tuberculosis
    disease control
    income
    Tuberculosis
    HIV
    therapeutics
    Screening
    screening
    signs and symptoms (animals and humans)
    control methods
    Therapeutics
    Tuberculin
    tuberculin
    skin tests
    Central Africa
    Southern Africa
    Central America

    ASJC Scopus subject areas

    • Biochemistry, Genetics and Molecular Biology(all)
    • Agricultural and Biological Sciences(all)
    • General

    Cite this

    Charles, M. K., Lindegren, M. L., Wester, C. W., Blevins, M., Sterling, T. R., Dung, N. T., ... International epidemiology Databases to Evaluate AIDS (IeDEA) Collaboration (2016). Implementation of tuberculosis intensive case finding, isoniazid preventive therapy, and infection control ("Three I's") and HIV-tuberculosis service integration in lower income countries. PloS one, 11(4), [e0153243]. https://doi.org/10.1371/journal.pone.0153243
    Charles, M. Katherine ; Lindegren, Mary Lou ; Wester, C. William ; Blevins, Meridith ; Sterling, Timothy R. ; Dung, Nguyen Thi ; Dusingize, Jean Claude ; Avit-Edi, Divine ; Durier, Nicolas ; Castelnuovo, Barbara ; Nakigozi, Gertrude ; Cortes, Claudia P. ; Ballif, Marie ; Fenner, Lukas ; Ajayi, Samuel ; Anastos, Kathryn ; Bashi, Jules ; Bishai, William ; Boulle, Andrew ; Braitstein, Paula ; Carriquiry, Gabriela ; Carter, Jane E. ; Cegielski, Peter ; Chimbetete, Cleophas ; Davies, Mary Ann ; Diero, Lameck ; Duda, Stephany ; Egger, Matthias ; Eboua, Tanoh F. ; Gasser, Adrian ; Geng, Elvin ; Gnokori, Joachim Charles ; Hardwicke, Laura ; Hoffmann, Chris ; Huebner, Robin ; Kancheya, Nzali ; Kiertiburanakul, Sasisopin ; Kim, Peter ; Lameck, Diero ; Leroy, Valériane ; Lewden, Charlotte ; Mandalakas, Anna ; Maskew, Mhairi ; McKaig, Rosemary ; Mofenson, Lynne ; Mpoudi-Etame, Mireille ; Okwara, Benson ; Phiri, Sam ; Prasitsuebsai, Wasana ; Wehbe, Firas ; International epidemiology Databases to Evaluate AIDS (IeDEA) Collaboration. / Implementation of tuberculosis intensive case finding, isoniazid preventive therapy, and infection control ("Three I's") and HIV-tuberculosis service integration in lower income countries. In: PloS one. 2016 ; Vol. 11, No. 4.
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    title = "Implementation of tuberculosis intensive case finding, isoniazid preventive therapy, and infection control ({"}Three I's{"}) and HIV-tuberculosis service integration in lower income countries",
    abstract = "Setting: World Health Organization advocates for integration of HIV-tuberculosis (TB) services and recommends intensive case finding (ICF), isoniazid preventive therapy (IPT), and infection control ({"}Three I's{"}) for TB prevention and control among persons living with HIV. Objective: To assess the implementation of the {"}Three I's{"} of TB-control at HIV treatment sites in lower income countries. Design: Survey conducted between March-July, 2012 at 47 sites in 26 countries: 6 (13{\%}) Asia Pacific, 7 (15{\%}), Caribbean, Central and South America, 5 (10{\%}) Central Africa, 8 (17{\%}) East Africa, 14 (30{\%}) Southern Africa, and 7 (15{\%}) West Africa. Results: ICF using symptom-based screening was performed at 38{\%} of sites; 45{\%} of sites used symptom-screening plus additional diagnostics. IPT at enrollment or ART initiation was implemented in only 17{\%} of sites, with 9{\%} of sites providing IPT to tuberculin-skin-test positive patients. Infection control measures varied: 62{\%} of sites separated smear-positive patients, and healthcare workers used masks at 57{\%} of sites. Only 12 (26{\%}) sites integrated HIV-TB services. Integration was not associated with implementation of TB prevention measures except for IPT provision at enrollment (42{\%} integrated vs. 9{\%} nonintegrated; p = 0.03). Conclusions: Implementation of TB screening, IPT provision, and infection control measures was low and variable across regional HIV treatment sites, regardless of integration status.",
    author = "Charles, {M. Katherine} and Lindegren, {Mary Lou} and Wester, {C. William} and Meridith Blevins and Sterling, {Timothy R.} and Dung, {Nguyen Thi} and Dusingize, {Jean Claude} and Divine Avit-Edi and Nicolas Durier and Barbara Castelnuovo and Gertrude Nakigozi and Cortes, {Claudia P.} and Marie Ballif and Lukas Fenner and Samuel Ajayi and Kathryn Anastos and Jules Bashi and William Bishai and Andrew Boulle and Paula Braitstein and Gabriela Carriquiry and Carter, {Jane E.} and Peter Cegielski and Cleophas Chimbetete and Davies, {Mary Ann} and Lameck Diero and Stephany Duda and Matthias Egger and Eboua, {Tanoh F.} and Adrian Gasser and Elvin Geng and Gnokori, {Joachim Charles} and Laura Hardwicke and Chris Hoffmann and Robin Huebner and Nzali Kancheya and Sasisopin Kiertiburanakul and Peter Kim and Diero Lameck and Val{\'e}riane Leroy and Charlotte Lewden and Anna Mandalakas and Mhairi Maskew and Rosemary McKaig and Lynne Mofenson and Mireille Mpoudi-Etame and Benson Okwara and Sam Phiri and Wasana Prasitsuebsai and Firas Wehbe and {International epidemiology Databases to Evaluate AIDS (IeDEA) Collaboration}",
    year = "2016",
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    doi = "10.1371/journal.pone.0153243",
    language = "English (US)",
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    Charles, MK, Lindegren, ML, Wester, CW, Blevins, M, Sterling, TR, Dung, NT, Dusingize, JC, Avit-Edi, D, Durier, N, Castelnuovo, B, Nakigozi, G, Cortes, CP, Ballif, M, Fenner, L, Ajayi, S, Anastos, K, Bashi, J, Bishai, W, Boulle, A, Braitstein, P, Carriquiry, G, Carter, JE, Cegielski, P, Chimbetete, C, Davies, MA, Diero, L, Duda, S, Egger, M, Eboua, TF, Gasser, A, Geng, E, Gnokori, JC, Hardwicke, L, Hoffmann, C, Huebner, R, Kancheya, N, Kiertiburanakul, S, Kim, P, Lameck, D, Leroy, V, Lewden, C, Mandalakas, A, Maskew, M, McKaig, R, Mofenson, L, Mpoudi-Etame, M, Okwara, B, Phiri, S, Prasitsuebsai, W, Wehbe, F & International epidemiology Databases to Evaluate AIDS (IeDEA) Collaboration 2016, 'Implementation of tuberculosis intensive case finding, isoniazid preventive therapy, and infection control ("Three I's") and HIV-tuberculosis service integration in lower income countries', PloS one, vol. 11, no. 4, e0153243. https://doi.org/10.1371/journal.pone.0153243

    Implementation of tuberculosis intensive case finding, isoniazid preventive therapy, and infection control ("Three I's") and HIV-tuberculosis service integration in lower income countries. / Charles, M. Katherine; Lindegren, Mary Lou; Wester, C. William; Blevins, Meridith; Sterling, Timothy R.; Dung, Nguyen Thi; Dusingize, Jean Claude; Avit-Edi, Divine; Durier, Nicolas; Castelnuovo, Barbara; Nakigozi, Gertrude; Cortes, Claudia P.; Ballif, Marie; Fenner, Lukas; Ajayi, Samuel; Anastos, Kathryn; Bashi, Jules; Bishai, William; Boulle, Andrew; Braitstein, Paula; Carriquiry, Gabriela; Carter, Jane E.; Cegielski, Peter; Chimbetete, Cleophas; Davies, Mary Ann; Diero, Lameck; Duda, Stephany; Egger, Matthias; Eboua, Tanoh F.; Gasser, Adrian; Geng, Elvin; Gnokori, Joachim Charles; Hardwicke, Laura; Hoffmann, Chris; Huebner, Robin; Kancheya, Nzali; Kiertiburanakul, Sasisopin; Kim, Peter; Lameck, Diero; Leroy, Valériane; Lewden, Charlotte; Mandalakas, Anna; Maskew, Mhairi; McKaig, Rosemary; Mofenson, Lynne; Mpoudi-Etame, Mireille; Okwara, Benson; Phiri, Sam; Prasitsuebsai, Wasana; Wehbe, Firas; International epidemiology Databases to Evaluate AIDS (IeDEA) Collaboration.

    In: PloS one, Vol. 11, No. 4, e0153243, 01.04.2016.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Implementation of tuberculosis intensive case finding, isoniazid preventive therapy, and infection control ("Three I's") and HIV-tuberculosis service integration in lower income countries

    AU - Charles, M. Katherine

    AU - Lindegren, Mary Lou

    AU - Wester, C. William

    AU - Blevins, Meridith

    AU - Sterling, Timothy R.

    AU - Dung, Nguyen Thi

    AU - Dusingize, Jean Claude

    AU - Avit-Edi, Divine

    AU - Durier, Nicolas

    AU - Castelnuovo, Barbara

    AU - Nakigozi, Gertrude

    AU - Cortes, Claudia P.

    AU - Ballif, Marie

    AU - Fenner, Lukas

    AU - Ajayi, Samuel

    AU - Anastos, Kathryn

    AU - Bashi, Jules

    AU - Bishai, William

    AU - Boulle, Andrew

    AU - Braitstein, Paula

    AU - Carriquiry, Gabriela

    AU - Carter, Jane E.

    AU - Cegielski, Peter

    AU - Chimbetete, Cleophas

    AU - Davies, Mary Ann

    AU - Diero, Lameck

    AU - Duda, Stephany

    AU - Egger, Matthias

    AU - Eboua, Tanoh F.

    AU - Gasser, Adrian

    AU - Geng, Elvin

    AU - Gnokori, Joachim Charles

    AU - Hardwicke, Laura

    AU - Hoffmann, Chris

    AU - Huebner, Robin

    AU - Kancheya, Nzali

    AU - Kiertiburanakul, Sasisopin

    AU - Kim, Peter

    AU - Lameck, Diero

    AU - Leroy, Valériane

    AU - Lewden, Charlotte

    AU - Mandalakas, Anna

    AU - Maskew, Mhairi

    AU - McKaig, Rosemary

    AU - Mofenson, Lynne

    AU - Mpoudi-Etame, Mireille

    AU - Okwara, Benson

    AU - Phiri, Sam

    AU - Prasitsuebsai, Wasana

    AU - Wehbe, Firas

    AU - International epidemiology Databases to Evaluate AIDS (IeDEA) Collaboration

    PY - 2016/4/1

    Y1 - 2016/4/1

    N2 - Setting: World Health Organization advocates for integration of HIV-tuberculosis (TB) services and recommends intensive case finding (ICF), isoniazid preventive therapy (IPT), and infection control ("Three I's") for TB prevention and control among persons living with HIV. Objective: To assess the implementation of the "Three I's" of TB-control at HIV treatment sites in lower income countries. Design: Survey conducted between March-July, 2012 at 47 sites in 26 countries: 6 (13%) Asia Pacific, 7 (15%), Caribbean, Central and South America, 5 (10%) Central Africa, 8 (17%) East Africa, 14 (30%) Southern Africa, and 7 (15%) West Africa. Results: ICF using symptom-based screening was performed at 38% of sites; 45% of sites used symptom-screening plus additional diagnostics. IPT at enrollment or ART initiation was implemented in only 17% of sites, with 9% of sites providing IPT to tuberculin-skin-test positive patients. Infection control measures varied: 62% of sites separated smear-positive patients, and healthcare workers used masks at 57% of sites. Only 12 (26%) sites integrated HIV-TB services. Integration was not associated with implementation of TB prevention measures except for IPT provision at enrollment (42% integrated vs. 9% nonintegrated; p = 0.03). Conclusions: Implementation of TB screening, IPT provision, and infection control measures was low and variable across regional HIV treatment sites, regardless of integration status.

    AB - Setting: World Health Organization advocates for integration of HIV-tuberculosis (TB) services and recommends intensive case finding (ICF), isoniazid preventive therapy (IPT), and infection control ("Three I's") for TB prevention and control among persons living with HIV. Objective: To assess the implementation of the "Three I's" of TB-control at HIV treatment sites in lower income countries. Design: Survey conducted between March-July, 2012 at 47 sites in 26 countries: 6 (13%) Asia Pacific, 7 (15%), Caribbean, Central and South America, 5 (10%) Central Africa, 8 (17%) East Africa, 14 (30%) Southern Africa, and 7 (15%) West Africa. Results: ICF using symptom-based screening was performed at 38% of sites; 45% of sites used symptom-screening plus additional diagnostics. IPT at enrollment or ART initiation was implemented in only 17% of sites, with 9% of sites providing IPT to tuberculin-skin-test positive patients. Infection control measures varied: 62% of sites separated smear-positive patients, and healthcare workers used masks at 57% of sites. Only 12 (26%) sites integrated HIV-TB services. Integration was not associated with implementation of TB prevention measures except for IPT provision at enrollment (42% integrated vs. 9% nonintegrated; p = 0.03). Conclusions: Implementation of TB screening, IPT provision, and infection control measures was low and variable across regional HIV treatment sites, regardless of integration status.

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    JO - PLoS One

    JF - PLoS One

    SN - 1932-6203

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