Implementation, recruitment and baseline characteristics

A randomized trial of combined treatments for smoking cessation and weight control

Terry Bush*, Jennifer Lovejoy, Harold Javitz, Stacey Mahuna, Alula Jimenez Torres, Ken Wassum, Brooke Magnusson, Cody Benedict, Bonnie Spring

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background Two-thirds of treatment-seeking smokers are obese or overweight. Most smokers are concerned about gaining weight after quitting. The average smoker experiences modest post-quit weight gain which discourages many smokers from quitting. Although evidence suggests that combined interventions to help smokers quit smoking and prevent weight gain can be helpful, studies have not been replicated in real world settings. Methods This paper describes recruitment and participant characteristics of the Best Quit Study, a 3-arm randomized controlled trial testing tobacco cessation treatment alone or combined with simultaneous or sequential weight management. Study participants were recruited via tobacco quitlines from August 5, 2013 to December 15, 2014. Results Statistical analysis on baseline data was conducted in 2015/2016. Among 5082 potentially eligible callers to a tobacco quitline, 2540 were randomized (50% of eligible). Compared with individuals eligible but not randomized, those randomized were significantly more likely to be female (65.7% vs 54.5%, p < 0.01), overweight or obese (76.3% vs 62.5%, p < 0.01), more confident in quitting (p < 0.01), more addicted (first cigarette within 5 min: 50.0% vs 44.4%, p < 0.01), and have a chronic disease (28.6% vs. 24.4%, p < 0.01). Randomized groups were not statistically significantly different on demographics, tobacco or weight variables. Two-thirds of participants were female and white with a mean age of 43. Conclusions Adding weight management interventions to tobacco cessation quitlines was feasible and acceptable to smokers. If successful for cessation and weight outcomes, a combined intervention may provide a treatment approach for addressing weight gain with smoking cessation through tobacco quitlines. Trial registration Clinicaltrials.gov NCT01867983.

Original languageEnglish (US)
Pages (from-to)95-102
Number of pages8
JournalContemporary Clinical Trials Communications
Volume7
DOIs
StatePublished - Sep 1 2017

Fingerprint

Smoking Cessation
Tobacco
Weights and Measures
Tobacco Use Cessation
Weight Gain
Therapeutics
Withholding Treatment
Tobacco Products
Chronic Disease
Randomized Controlled Trials
Smoking
Demography

Keywords

  • Quitlines
  • Sequential
  • Simultaneous
  • Smoking
  • Weight gain

ASJC Scopus subject areas

  • Pharmacology

Cite this

Bush, Terry ; Lovejoy, Jennifer ; Javitz, Harold ; Mahuna, Stacey ; Torres, Alula Jimenez ; Wassum, Ken ; Magnusson, Brooke ; Benedict, Cody ; Spring, Bonnie. / Implementation, recruitment and baseline characteristics : A randomized trial of combined treatments for smoking cessation and weight control. In: Contemporary Clinical Trials Communications. 2017 ; Vol. 7. pp. 95-102.
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title = "Implementation, recruitment and baseline characteristics: A randomized trial of combined treatments for smoking cessation and weight control",
abstract = "Background Two-thirds of treatment-seeking smokers are obese or overweight. Most smokers are concerned about gaining weight after quitting. The average smoker experiences modest post-quit weight gain which discourages many smokers from quitting. Although evidence suggests that combined interventions to help smokers quit smoking and prevent weight gain can be helpful, studies have not been replicated in real world settings. Methods This paper describes recruitment and participant characteristics of the Best Quit Study, a 3-arm randomized controlled trial testing tobacco cessation treatment alone or combined with simultaneous or sequential weight management. Study participants were recruited via tobacco quitlines from August 5, 2013 to December 15, 2014. Results Statistical analysis on baseline data was conducted in 2015/2016. Among 5082 potentially eligible callers to a tobacco quitline, 2540 were randomized (50{\%} of eligible). Compared with individuals eligible but not randomized, those randomized were significantly more likely to be female (65.7{\%} vs 54.5{\%}, p < 0.01), overweight or obese (76.3{\%} vs 62.5{\%}, p < 0.01), more confident in quitting (p < 0.01), more addicted (first cigarette within 5 min: 50.0{\%} vs 44.4{\%}, p < 0.01), and have a chronic disease (28.6{\%} vs. 24.4{\%}, p < 0.01). Randomized groups were not statistically significantly different on demographics, tobacco or weight variables. Two-thirds of participants were female and white with a mean age of 43. Conclusions Adding weight management interventions to tobacco cessation quitlines was feasible and acceptable to smokers. If successful for cessation and weight outcomes, a combined intervention may provide a treatment approach for addressing weight gain with smoking cessation through tobacco quitlines. Trial registration Clinicaltrials.gov NCT01867983.",
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Implementation, recruitment and baseline characteristics : A randomized trial of combined treatments for smoking cessation and weight control. / Bush, Terry; Lovejoy, Jennifer; Javitz, Harold; Mahuna, Stacey; Torres, Alula Jimenez; Wassum, Ken; Magnusson, Brooke; Benedict, Cody; Spring, Bonnie.

In: Contemporary Clinical Trials Communications, Vol. 7, 01.09.2017, p. 95-102.

Research output: Contribution to journalArticle

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T1 - Implementation, recruitment and baseline characteristics

T2 - A randomized trial of combined treatments for smoking cessation and weight control

AU - Bush, Terry

AU - Lovejoy, Jennifer

AU - Javitz, Harold

AU - Mahuna, Stacey

AU - Torres, Alula Jimenez

AU - Wassum, Ken

AU - Magnusson, Brooke

AU - Benedict, Cody

AU - Spring, Bonnie

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N2 - Background Two-thirds of treatment-seeking smokers are obese or overweight. Most smokers are concerned about gaining weight after quitting. The average smoker experiences modest post-quit weight gain which discourages many smokers from quitting. Although evidence suggests that combined interventions to help smokers quit smoking and prevent weight gain can be helpful, studies have not been replicated in real world settings. Methods This paper describes recruitment and participant characteristics of the Best Quit Study, a 3-arm randomized controlled trial testing tobacco cessation treatment alone or combined with simultaneous or sequential weight management. Study participants were recruited via tobacco quitlines from August 5, 2013 to December 15, 2014. Results Statistical analysis on baseline data was conducted in 2015/2016. Among 5082 potentially eligible callers to a tobacco quitline, 2540 were randomized (50% of eligible). Compared with individuals eligible but not randomized, those randomized were significantly more likely to be female (65.7% vs 54.5%, p < 0.01), overweight or obese (76.3% vs 62.5%, p < 0.01), more confident in quitting (p < 0.01), more addicted (first cigarette within 5 min: 50.0% vs 44.4%, p < 0.01), and have a chronic disease (28.6% vs. 24.4%, p < 0.01). Randomized groups were not statistically significantly different on demographics, tobacco or weight variables. Two-thirds of participants were female and white with a mean age of 43. Conclusions Adding weight management interventions to tobacco cessation quitlines was feasible and acceptable to smokers. If successful for cessation and weight outcomes, a combined intervention may provide a treatment approach for addressing weight gain with smoking cessation through tobacco quitlines. Trial registration Clinicaltrials.gov NCT01867983.

AB - Background Two-thirds of treatment-seeking smokers are obese or overweight. Most smokers are concerned about gaining weight after quitting. The average smoker experiences modest post-quit weight gain which discourages many smokers from quitting. Although evidence suggests that combined interventions to help smokers quit smoking and prevent weight gain can be helpful, studies have not been replicated in real world settings. Methods This paper describes recruitment and participant characteristics of the Best Quit Study, a 3-arm randomized controlled trial testing tobacco cessation treatment alone or combined with simultaneous or sequential weight management. Study participants were recruited via tobacco quitlines from August 5, 2013 to December 15, 2014. Results Statistical analysis on baseline data was conducted in 2015/2016. Among 5082 potentially eligible callers to a tobacco quitline, 2540 were randomized (50% of eligible). Compared with individuals eligible but not randomized, those randomized were significantly more likely to be female (65.7% vs 54.5%, p < 0.01), overweight or obese (76.3% vs 62.5%, p < 0.01), more confident in quitting (p < 0.01), more addicted (first cigarette within 5 min: 50.0% vs 44.4%, p < 0.01), and have a chronic disease (28.6% vs. 24.4%, p < 0.01). Randomized groups were not statistically significantly different on demographics, tobacco or weight variables. Two-thirds of participants were female and white with a mean age of 43. Conclusions Adding weight management interventions to tobacco cessation quitlines was feasible and acceptable to smokers. If successful for cessation and weight outcomes, a combined intervention may provide a treatment approach for addressing weight gain with smoking cessation through tobacco quitlines. Trial registration Clinicaltrials.gov NCT01867983.

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