Implications for reactive oxygen species in schizophrenia pathogenesis

Minori Koga, Anthony V. Serritella, Akira Sawa, Thomas W. Sedlak*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

75 Scopus citations

Abstract

Oxidative stress is a well-recognized participant in the pathophysiology of multiple brain disorders, particularly neurodegenerative conditions such as Alzheimer's and Parkinson's diseases. While not a dementia, a wide body of evidence has also been accumulating for aberrant reactive oxygen species and inflammation in schizophrenia. Here we highlight roles for oxidative stress as a common mechanism by which varied genetic and epidemiologic risk factors impact upon neurodevelopmental processes that underlie the schizophrenia syndrome. While there is longstanding evidence that schizophrenia may not have a single causative lesion, a common pathway involving oxidative stress opens the possibility for intervention at susceptible phases.

Original languageEnglish (US)
Pages (from-to)52-71
Number of pages20
JournalSchizophrenia Research
Volume176
Issue number1
DOIs
StatePublished - Sep 1 2016
Externally publishedYes

Keywords

  • Glutathione
  • Inflammation
  • Microglia
  • Oxidative stress
  • Psychosis
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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