Implications of functional proteomics in breast cancer

Young Kwang Chae, Ana Maria Gonzalez-Angulo

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Breast cancer is one of the major public health problems of the Western world. Recent advances in genomics and gene expression-profiling approaches have enriched our understanding of this heterogeneous disease. However, progress in functional proteomics in breast cancer research has been relatively slow. Allied with genomics, the functional proteomics approach will be important in improving diagnosis through better classification of breast cancer and in predicting prognosis and response to different therapies, including chemotherapy, hormonal therapy, and targeted therapy. In this review, we will present functional proteomic approaches with a focus on the recent clinical implications of utilizing the reverse-phase protein array platform in breast cancer research.

Original languageEnglish (US)
Pages (from-to)328-335
Number of pages8
JournalOncologist
Volume19
Issue number4
DOIs
StatePublished - 2014

Keywords

  • Breast cancer
  • Functional proteomics
  • Predictive marker
  • Prognostic marker

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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