Implications of 'low maternal serum alpha‐fetoprotein levels: Are maternal age risk criteria obsolete?

Alice O. Martin*, Kiang Liu

*Corresponding author for this work

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

An association has been reported between “low” maternal serum alpha‐fetoprotein (MSAFP) and fetal chromosome abnormalities, notably Down syndrome. We suggest the predictive value be used for genetic counselling when a “low” MSAFP is found, and present an illustrative risk table. It can also be seen that normal MSAFP in a woman may lower her age‐related risks below that previously defined as “high risk”. However, until good estimates of sensitivity and specificity are available from prospective, population based studies, patients should be told that any risk estimates are rough approximations. When good estimates are available, use of age risks alone may become obsolete.

Original languageEnglish (US)
Pages (from-to)243-247
Number of pages5
JournalPrenatal Diagnosis
Volume6
Issue number4
DOIs
StatePublished - Jan 1 1986

Keywords

  • Low values Risk
  • Maternal serum alpha‐fetoprotein

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Genetics(clinical)

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