Importance of cochlear health for implant function

Bryan E. Pfingst; Ning Zhou; Deborah J. Colesa; Melissa M. Watts; Stefan B. Strahl; Soha N. Garadat; Kara C. Schvartz-Leyzac; Cameron L. Budenz; Yehoash Raphael; Teresa A. Zwolan

doi:10.1016/j.heares.2014.09.009

Importance of cochlear health for implant function

Bryan E. Pfingst^*, Ning Zhou, Deborah J. Colesa, Melissa M. Watts, Stefan B. Strahl, Soha N. Garadat, Kara C. Schvartz-Leyzac, Cameron L. Budenz, Yehoash Raphael, Teresa A. Zwolan

^*Corresponding author for this work

Medicine, Allergy Division

Research output: Contribution to journal › Review article › peer-review

110 Scopus citations

Abstract

Amazing progress has been made in providing useful hearing to hearing-impaired individuals using cochlear implants, but challenges remain. One such challenge is understanding the effects of partial degeneration of the auditory nerve, the target of cochlear implant stimulation. Here we review studies from our human and animal laboratories aimed at characterizing the health of the implanted cochlea and the auditory nerve. We use the data on cochlear and neural health to guide rehabilitation strategies. The data also motivate the development of tissue-engineering procedures to preserve or build a healthy cochlea and improve performance obtained by cochlear implant recipients or eventually replace the need for a cochlear implant. This article is part of a Special Issue entitled <Lasker Award>.

Original language	English (US)
Pages (from-to)	77-88
Number of pages	12
Journal	Hearing research
Volume	322
DOIs	https://doi.org/10.1016/j.heares.2014.09.009
State	Published - Apr 1 2015

Funding

The research was supported by NIH-NIDCD R01 DC010786, R01 DC 007634, R01 DC010412, T32 DC00011, T32 DC005356 and P30 DC05188, the U. of M. Center for Organogenesis and a contract from MED-EL. We thank our dedicated subjects with cochlear implants for participation in these studies. We thank Caroline Arnedt, Jennifer Benson, Lisa Beyer, Raisa Gao, Elizabeth Hyde, Lisa Kabara, Moaz Sinan, Gina Su and Donald Swiderski, for their assistance with data collection and analysis.

Keywords

AAV
ASM
Ad
BDNF
C level
CUNY sentences
DPI
EABR
ECAP
GDT
IHC
MDT
MPI
N1
NT-3
NTF-3
P2
SGN
SNR
T level
TI

ASJC Scopus subject areas

Sensory Systems

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10.1016/j.heares.2014.09.009

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title = "Importance of cochlear health for implant function",

abstract = "Amazing progress has been made in providing useful hearing to hearing-impaired individuals using cochlear implants, but challenges remain. One such challenge is understanding the effects of partial degeneration of the auditory nerve, the target of cochlear implant stimulation. Here we review studies from our human and animal laboratories aimed at characterizing the health of the implanted cochlea and the auditory nerve. We use the data on cochlear and neural health to guide rehabilitation strategies. The data also motivate the development of tissue-engineering procedures to preserve or build a healthy cochlea and improve performance obtained by cochlear implant recipients or eventually replace the need for a cochlear implant. This article is part of a Special Issue entitled .",

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author = "Pfingst, {Bryan E.} and Ning Zhou and Colesa, {Deborah J.} and Watts, {Melissa M.} and Strahl, {Stefan B.} and Garadat, {Soha N.} and Schvartz-Leyzac, {Kara C.} and Budenz, {Cameron L.} and Yehoash Raphael and Zwolan, {Teresa A.}",

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doi = "10.1016/j.heares.2014.09.009",

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AU - Zhou, Ning

AU - Colesa, Deborah J.

AU - Watts, Melissa M.

AU - Strahl, Stefan B.

AU - Garadat, Soha N.

AU - Schvartz-Leyzac, Kara C.

AU - Budenz, Cameron L.

AU - Raphael, Yehoash

AU - Zwolan, Teresa A.

PY - 2015/4/1

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N2 - Amazing progress has been made in providing useful hearing to hearing-impaired individuals using cochlear implants, but challenges remain. One such challenge is understanding the effects of partial degeneration of the auditory nerve, the target of cochlear implant stimulation. Here we review studies from our human and animal laboratories aimed at characterizing the health of the implanted cochlea and the auditory nerve. We use the data on cochlear and neural health to guide rehabilitation strategies. The data also motivate the development of tissue-engineering procedures to preserve or build a healthy cochlea and improve performance obtained by cochlear implant recipients or eventually replace the need for a cochlear implant. This article is part of a Special Issue entitled .

AB - Amazing progress has been made in providing useful hearing to hearing-impaired individuals using cochlear implants, but challenges remain. One such challenge is understanding the effects of partial degeneration of the auditory nerve, the target of cochlear implant stimulation. Here we review studies from our human and animal laboratories aimed at characterizing the health of the implanted cochlea and the auditory nerve. We use the data on cochlear and neural health to guide rehabilitation strategies. The data also motivate the development of tissue-engineering procedures to preserve or build a healthy cochlea and improve performance obtained by cochlear implant recipients or eventually replace the need for a cochlear implant. This article is part of a Special Issue entitled .

KW - AAV

KW - ASM

KW - Ad

KW - BDNF

KW - C level

KW - CUNY sentences

KW - DPI

KW - EABR

KW - ECAP

KW - GDT

KW - IHC

KW - MDT

KW - MPI

KW - N1

KW - NT-3

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JO - Hearing research

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ER -

Importance of cochlear health for implant function

Abstract

Funding

Keywords

ASJC Scopus subject areas

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