Importance of cochlear health for implant function

Bryan E. Pfingst*, Ning Zhou, Deborah J. Colesa, Melissa M. Watts, Stefan B. Strahl, Soha N. Garadat, Kara C. Schvartz-Leyzac, Cameron L. Budenz, Yehoash Raphael, Teresa A. Zwolan

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

71 Scopus citations

Abstract

Amazing progress has been made in providing useful hearing to hearing-impaired individuals using cochlear implants, but challenges remain. One such challenge is understanding the effects of partial degeneration of the auditory nerve, the target of cochlear implant stimulation. Here we review studies from our human and animal laboratories aimed at characterizing the health of the implanted cochlea and the auditory nerve. We use the data on cochlear and neural health to guide rehabilitation strategies. The data also motivate the development of tissue-engineering procedures to preserve or build a healthy cochlea and improve performance obtained by cochlear implant recipients or eventually replace the need for a cochlear implant. This article is part of a Special Issue entitled <Lasker Award>.

Original languageEnglish (US)
Pages (from-to)77-88
Number of pages12
JournalHearing research
Volume322
DOIs
StatePublished - Apr 1 2015
Externally publishedYes

Keywords

  • AAV
  • ASM
  • Ad
  • BDNF
  • C level
  • CUNY sentences
  • DPI
  • EABR
  • ECAP
  • GDT
  • IHC
  • MDT
  • MPI
  • N1
  • NT-3
  • NTF-3
  • P2
  • SGN
  • SNR
  • T level
  • TI

ASJC Scopus subject areas

  • Sensory Systems

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