Importance of cochlear health for implant function

Bryan E. Pfingst; Ning Zhou; Deborah J. Colesa; Melissa M. Watts; Stefan B. Strahl; Soha N. Garadat; Kara C. Schvartz-Leyzac; Cameron L. Budenz; Yehoash Raphael; Teresa A. Zwolan

doi:10.1016/j.heares.2014.09.009

Importance of cochlear health for implant function

Bryan E. Pfingst^*, Ning Zhou, Deborah J. Colesa, Melissa M. Watts, Stefan B. Strahl, Soha N. Garadat, Kara C. Schvartz-Leyzac, Cameron L. Budenz, Yehoash Raphael, Teresa A. Zwolan

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

71 Scopus citations

Abstract

Amazing progress has been made in providing useful hearing to hearing-impaired individuals using cochlear implants, but challenges remain. One such challenge is understanding the effects of partial degeneration of the auditory nerve, the target of cochlear implant stimulation. Here we review studies from our human and animal laboratories aimed at characterizing the health of the implanted cochlea and the auditory nerve. We use the data on cochlear and neural health to guide rehabilitation strategies. The data also motivate the development of tissue-engineering procedures to preserve or build a healthy cochlea and improve performance obtained by cochlear implant recipients or eventually replace the need for a cochlear implant. This article is part of a Special Issue entitled <Lasker Award>.

Original language	English (US)
Pages (from-to)	77-88
Number of pages	12
Journal	Hearing research
Volume	322
DOIs	https://doi.org/10.1016/j.heares.2014.09.009
State	Published - Apr 1 2015
Externally published	Yes

Keywords

AAV
ASM
Ad
BDNF
C level
CUNY sentences
DPI
EABR
ECAP
GDT
IHC
MDT
MPI
N1
NT-3
NTF-3
P2
SGN
SNR
T level
TI

ASJC Scopus subject areas

Sensory Systems

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.heares.2014.09.009

Cite this

@article{905aa784e62d44fc96323d1c37c1adbb,

title = "Importance of cochlear health for implant function",

abstract = "Amazing progress has been made in providing useful hearing to hearing-impaired individuals using cochlear implants, but challenges remain. One such challenge is understanding the effects of partial degeneration of the auditory nerve, the target of cochlear implant stimulation. Here we review studies from our human and animal laboratories aimed at characterizing the health of the implanted cochlea and the auditory nerve. We use the data on cochlear and neural health to guide rehabilitation strategies. The data also motivate the development of tissue-engineering procedures to preserve or build a healthy cochlea and improve performance obtained by cochlear implant recipients or eventually replace the need for a cochlear implant. This article is part of a Special Issue entitled <Lasker Award>.",

keywords = "AAV, ASM, Ad, BDNF, C level, CUNY sentences, DPI, EABR, ECAP, GDT, IHC, MDT, MPI, N1, NT-3, NTF-3, P2, SGN, SNR, T level, TI",

author = "Pfingst, {Bryan E.} and Ning Zhou and Colesa, {Deborah J.} and Watts, {Melissa M.} and Strahl, {Stefan B.} and Garadat, {Soha N.} and Schvartz-Leyzac, {Kara C.} and Budenz, {Cameron L.} and Yehoash Raphael and Zwolan, {Teresa A.}",

note = "Funding Information: The research was supported by NIH-NIDCD R01 DC010786, R01 DC 007634, R01 DC010412, T32 DC00011, T32 DC005356 and P30 DC05188, the U. of M. Center for Organogenesis and a contract from MED-EL. We thank our dedicated subjects with cochlear implants for participation in these studies. We thank Caroline Arnedt, Jennifer Benson, Lisa Beyer, Raisa Gao, Elizabeth Hyde, Lisa Kabara, Moaz Sinan, Gina Su and Donald Swiderski, for their assistance with data collection and analysis. Publisher Copyright: {\textcopyright} 2014 Elsevier B.V.",

year = "2015",

month = apr,

day = "1",

doi = "10.1016/j.heares.2014.09.009",

language = "English (US)",

volume = "322",

pages = "77--88",

journal = "Hearing Research",

issn = "0378-5955",

publisher = "Elsevier",

}

Importance of cochlear health for implant function. / Pfingst, Bryan E.; Zhou, Ning; Colesa, Deborah J.; Watts, Melissa M.; Strahl, Stefan B.; Garadat, Soha N.; Schvartz-Leyzac, Kara C.; Budenz, Cameron L.; Raphael, Yehoash; Zwolan, Teresa A.

In: Hearing research, Vol. 322, 01.04.2015, p. 77-88.

Research output: Contribution to journal › Review article › peer-review

TY - JOUR

T1 - Importance of cochlear health for implant function

AU - Pfingst, Bryan E.

AU - Zhou, Ning

AU - Colesa, Deborah J.

AU - Watts, Melissa M.

AU - Strahl, Stefan B.

AU - Garadat, Soha N.

AU - Schvartz-Leyzac, Kara C.

AU - Budenz, Cameron L.

AU - Raphael, Yehoash

AU - Zwolan, Teresa A.

N1 - Funding Information: The research was supported by NIH-NIDCD R01 DC010786, R01 DC 007634, R01 DC010412, T32 DC00011, T32 DC005356 and P30 DC05188, the U. of M. Center for Organogenesis and a contract from MED-EL. We thank our dedicated subjects with cochlear implants for participation in these studies. We thank Caroline Arnedt, Jennifer Benson, Lisa Beyer, Raisa Gao, Elizabeth Hyde, Lisa Kabara, Moaz Sinan, Gina Su and Donald Swiderski, for their assistance with data collection and analysis. Publisher Copyright: © 2014 Elsevier B.V.

PY - 2015/4/1

Y1 - 2015/4/1

N2 - Amazing progress has been made in providing useful hearing to hearing-impaired individuals using cochlear implants, but challenges remain. One such challenge is understanding the effects of partial degeneration of the auditory nerve, the target of cochlear implant stimulation. Here we review studies from our human and animal laboratories aimed at characterizing the health of the implanted cochlea and the auditory nerve. We use the data on cochlear and neural health to guide rehabilitation strategies. The data also motivate the development of tissue-engineering procedures to preserve or build a healthy cochlea and improve performance obtained by cochlear implant recipients or eventually replace the need for a cochlear implant. This article is part of a Special Issue entitled <Lasker Award>.

AB - Amazing progress has been made in providing useful hearing to hearing-impaired individuals using cochlear implants, but challenges remain. One such challenge is understanding the effects of partial degeneration of the auditory nerve, the target of cochlear implant stimulation. Here we review studies from our human and animal laboratories aimed at characterizing the health of the implanted cochlea and the auditory nerve. We use the data on cochlear and neural health to guide rehabilitation strategies. The data also motivate the development of tissue-engineering procedures to preserve or build a healthy cochlea and improve performance obtained by cochlear implant recipients or eventually replace the need for a cochlear implant. This article is part of a Special Issue entitled <Lasker Award>.

KW - AAV

KW - ASM

KW - Ad

KW - BDNF

KW - C level

KW - CUNY sentences

KW - DPI

KW - EABR

KW - ECAP

KW - GDT

KW - IHC

KW - MDT

KW - MPI

KW - N1

KW - NT-3

KW - NTF-3

KW - P2

KW - SGN

KW - SNR

KW - T level

KW - TI

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UR - http://www.scopus.com/inward/citedby.url?scp=84925414358&partnerID=8YFLogxK

U2 - 10.1016/j.heares.2014.09.009

DO - 10.1016/j.heares.2014.09.009

M3 - Review article

C2 - 25261772

AN - SCOPUS:84925414358

VL - 322

SP - 77

EP - 88

JO - Hearing Research

JF - Hearing Research

SN - 0378-5955

ER -

Importance of cochlear health for implant function

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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