Improved anti-proliferative effect of doxorubicin-containing polymer nanoparticles upon surface modification with cationic groups

Sai Archana Krovi, Elden P. Swindell, Thomas V. O'Halloran, Sonbinh T. Nguyen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Polymer nanoparticles (PNPs) possessing a high density of drug payload have been successfully stabilized against aggregation in biological buffers after amine modification, which renders these PNPs positively charged. The resulting charge-stabilized PNPs retain their original narrow particle size distributions and well-defined spherical morphologies. This stabilization allows these PNPs to have an improved anti-proliferative effect on MDA-MB-231-Br human breast cancer cells compared to non-functionalized PNPs. As a non-cytotoxic control, similar surface-modified PNPs containing cholesterol in place of doxorubicin did not inhibit cell proliferation, indicating that the induced cytotoxic response was solely due to the doxorubicin release from the PNPs.

Original languageEnglish (US)
Pages (from-to)25463-25470
Number of pages8
JournalJournal of Materials Chemistry
Volume22
Issue number48
DOIs
StatePublished - Dec 28 2012

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Chemistry

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