Improved in vivo photoacoustic microscopy based on a virtual-detector concept

Meng Lin Li*, Hao F. Zhang, Konstantin Maslov, George Stoica, Lihong V. Wang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

136 Scopus citations

Abstract

Recently an in vivo high-resolution backward-mode photoacoustic microscope was developed that shows potential for applications in dermatology and related cancer research. However, the limited depth of focus of the large-numerical- aperture (NA) ultrasonic lens employed in this system causes the image quality to deteriorate significantly in the out-of-focus region. To solve this problem, we devised and explored, for the first time to our knowledge, a virtual-detector-based synthetic-aperture focusing technique, combined with coherence weighting, for photoacoustic microscopy with such a large-NA transducer. Images of phantoms show that the proposed technique improves the -6 dB lateral resolution from 49-379 to 46-53 μm and increases the signal-to-noise ratio by up to 29 dB, depending on the distance from the ultrasonic focal point. In vivo experiments show that the technique also provides a clearer representation of the vascular distribution in the rat's scalp.

Original languageEnglish (US)
Pages (from-to)474-476
Number of pages3
JournalOptics Letters
Volume31
Issue number4
DOIs
StatePublished - Feb 15 2006

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

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