Improved patient safety through reduced airway infection rates in a paediatric cystic fibrosis programme after a quality improvement effort to enhance infection prevention and control measures

Objective: To reduce the risk of pathogen transmission between patients with cystic fibrosis (CF) and decrease the rate of acquisition of new CF pathogens in our patients. Design: Using the Model for Improvement, we developed a new process for infection prevention and control in our outpatient CF clinics. Setting: Paediatric CF programme at Ann & Robert H. Lurie Children's Hospital of Chicago; approximately 180 paediatric patients aged birth to 21 years. Participants: All paediatric patients enrolled in the Cystic Fibrosis Foundation Patient Data Registry at this institution. Interventions: Implemented contact precautions with all patients, regardless of respiratory tract culture results. Measurement: Respiratory tract culture rates of specific pathogens by quarter were compared prior to and after implementation. Results: Our percentage of patients with a positive respiratory tract culture for Pseudomonas aeruginosa dropped from 30%to 21% (p<0.0001) and for methicillin-resistant Staphylococcus aureus (MRSA) dropped from 10.8%to 8.7%(p=0.008). Conclusions: Use of contact precautions by all care providers, for all patients, regardless of respiratory tract culture results resulted in decreased P aeruginosa and MRSA infection rates.