Abstract
We have devised a method of achieving the much-used macrocyclic polyether, 1,5-dinaphtho[38]crown-10, in three steps by a route that is more efficient and requires fewer purification procedures than those reported in the literature to date. The strategy can also be extended to the synthesis of asymmetric crown-10 ether derivatives with one 1,5-dinaphtho ring system.
Original language | English (US) |
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Pages (from-to) | 983-986 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 51 |
Issue number | 6 |
DOIs | |
State | Published - Feb 10 2010 |
Keywords
- Crown ethers
- Macrocyclic polyethers
- Mechanically interlocked molecules
- Templates
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry