Improvement in the function of hibernating myocardium in a patient with heart failure due to coronary artery disease receiving high-dose simvastatin

Mihai Gheorghiade*, Liviu Klein, Neil J. Stone, Robert O. Bonow, Raymond J. Kim

*Corresponding author for this work

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

We report the case of a 70-year-old man with a history of myocardial infarction and coronary artery bypass grafting, presenting with signs and symptoms of heart failure. Cardiac magnetic resonance imaging demonstrated a small amount of scarring in the anteroseptal wall, moderate left ventricular enlargement, and a left ventricular ejection fraction of 26%. Patient was started on simvastatin 20 mg daily, gradually increased to 80 mg daily, which were maintained for another 4 weeks. Twelve weeks after the initial presentation, the patient experienced a marked improvement in his symptoms. Repeat cardiac magnetic resonance imaging showed global improvement in left ventricular contractility, with ejection fraction of 36% and end-diastolic volume decreasing from 230 to 153 ml. We speculate that high-dose statin therapy had a significant role in improving the ventricular function in our patient by improving the endothelial flow. This hypothesis is presently being tested in a larger prospective trial.

Original languageEnglish (US)
Pages (from-to)160-162
Number of pages3
JournalItalian Heart Journal
Volume5
Issue number2
StatePublished - Feb 1 2004

Keywords

  • Coronary artery disease
  • Heart failure
  • Stunned myocardium

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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