Improvement of cardiac function persists long term with medical therapy for left ventricular systolic dysfunction

David Chen, Richard Chang, Branavan Umakanthan, Liset N. Stoletniy, J. Thomas Heywood*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

In certain patients with left ventricular (LV) systolic dysfunction, improvements in cardiac function are seen after initiation of medical therapy; however, the long-term stability of ventricular function in such patients is not well described. We retrospectively analyzed 171 patients who had a baseline ejection fraction of 45% or less, a follow-up echocardiogram at 2 to 12 months after initiation of medical therapy, and a final echocardiogram. We found that 48.5% of the patients demonstrated initial improvements in LV function after initiation of medical therapy, and the improvements appear to be sustained (88% of patients) at 44 ± 21 months follow-up. A nonischemic etiology and younger age were the only independent predictors of change of LV ejection fraction of 10 or more at a mean 8.4 ± 3.4 months after optimal medical therapy. Our study revealed a trend toward improved long-term survival in individuals with an early improvement in LV ejection fraction with medical therapy, especially in those with sustained improvement.

Original languageEnglish (US)
Pages (from-to)220-226
Number of pages7
JournalJournal of Cardiovascular Pharmacology and Therapeutics
Volume12
Issue number3
DOIs
StatePublished - Sep 1 2007

Keywords

  • Heart failure
  • Left ventricular systolic dysfunction
  • Medical therapy
  • Mortality

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine
  • Pharmacology (medical)

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