Improvement of naturally aged skin with vitamin A (Retinol)

Reza Kafi, Heh Shin R Kwak, Wendy E. Schumacher, Soyun Cho, Valerie N. Hanft, Ted A. Hamilton, Anya L. King, Jacqueline D. Neal, James Varani, Gary J. Fisher, John J. Voorhees, Sewon Kang*

*Corresponding author for this work

Research output: Contribution to journalArticle

112 Citations (Scopus)

Abstract

Objective: To evaluate the effectiveness of topical retinol (vitamin A) in improving the clinical signs of naturally aged skin. Design: Randomized, double-blind, vehicle-controlled, left and right arm comparison study. Setting: Academic referral center. Patients: The study population comprised 36 elderly subjects (mean age, 87 years), residing in 2 senior citizen facilities. Intervention: Topical 0.4% retinol lotion or its vehicle was applied at each visit by study personnel to either the right or the left arm, up to 3 times a week for 24 weeks. Main Outcome Measures: Clinical assessment using a semiquantitative scale (0, none; 9, most severe) and biochemical measurements from skin biopsy specimens obtained from treated areas. Results: After 24 weeks, an intent-to-treat analysis using the last-observation-carried-forward method revealed that there were significant differences between retinol-treated and vehicle-treated skin for changes in fine wrinkling scores (-1.64 [95% CI, -2.06 to -1.22] vs -0.08 [95% CI, -0.17 to 0.01]; P<.001). As measured in a subgroup, retinol treatment significantly increased glycosaminoglycan expression (P=.02 [n=6]) and procollagen I immunostaining (P=.049 [n=4]) compared with vehicle. Conclusions: Topical retinol improves fine wrinkles associated with natural aging. Significant induction of glycosaminoglycan, which is known to retain substantial water, and increased collagen production are most likely responsible for wrinkle effacement. With greater skin matrix synthesis, retinol-treated aged skin is more likely to withstand skin injury and ulcer formation along with improved appearance. Trial Registration: clinicaltrials.gov Identifier: NCT00272610

Original languageEnglish (US)
Pages (from-to)606-612
Number of pages7
JournalArchives of dermatology
Volume143
Issue number5
DOIs
StatePublished - May 1 2007

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Vitamin A
Skin
Glycosaminoglycans
Skin Ulcer
Procollagen
Collagen
Referral and Consultation
Observation
Outcome Assessment (Health Care)
Biopsy
Water
Wounds and Injuries
Population

ASJC Scopus subject areas

  • Dermatology

Cite this

Kafi, R., Kwak, H. S. R., Schumacher, W. E., Cho, S., Hanft, V. N., Hamilton, T. A., ... Kang, S. (2007). Improvement of naturally aged skin with vitamin A (Retinol). Archives of dermatology, 143(5), 606-612. https://doi.org/10.1001/archderm.143.5.606
Kafi, Reza ; Kwak, Heh Shin R ; Schumacher, Wendy E. ; Cho, Soyun ; Hanft, Valerie N. ; Hamilton, Ted A. ; King, Anya L. ; Neal, Jacqueline D. ; Varani, James ; Fisher, Gary J. ; Voorhees, John J. ; Kang, Sewon. / Improvement of naturally aged skin with vitamin A (Retinol). In: Archives of dermatology. 2007 ; Vol. 143, No. 5. pp. 606-612.
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abstract = "Objective: To evaluate the effectiveness of topical retinol (vitamin A) in improving the clinical signs of naturally aged skin. Design: Randomized, double-blind, vehicle-controlled, left and right arm comparison study. Setting: Academic referral center. Patients: The study population comprised 36 elderly subjects (mean age, 87 years), residing in 2 senior citizen facilities. Intervention: Topical 0.4{\%} retinol lotion or its vehicle was applied at each visit by study personnel to either the right or the left arm, up to 3 times a week for 24 weeks. Main Outcome Measures: Clinical assessment using a semiquantitative scale (0, none; 9, most severe) and biochemical measurements from skin biopsy specimens obtained from treated areas. Results: After 24 weeks, an intent-to-treat analysis using the last-observation-carried-forward method revealed that there were significant differences between retinol-treated and vehicle-treated skin for changes in fine wrinkling scores (-1.64 [95{\%} CI, -2.06 to -1.22] vs -0.08 [95{\%} CI, -0.17 to 0.01]; P<.001). As measured in a subgroup, retinol treatment significantly increased glycosaminoglycan expression (P=.02 [n=6]) and procollagen I immunostaining (P=.049 [n=4]) compared with vehicle. Conclusions: Topical retinol improves fine wrinkles associated with natural aging. Significant induction of glycosaminoglycan, which is known to retain substantial water, and increased collagen production are most likely responsible for wrinkle effacement. With greater skin matrix synthesis, retinol-treated aged skin is more likely to withstand skin injury and ulcer formation along with improved appearance. Trial Registration: clinicaltrials.gov Identifier: NCT00272610",
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Kafi, R, Kwak, HSR, Schumacher, WE, Cho, S, Hanft, VN, Hamilton, TA, King, AL, Neal, JD, Varani, J, Fisher, GJ, Voorhees, JJ & Kang, S 2007, 'Improvement of naturally aged skin with vitamin A (Retinol)', Archives of dermatology, vol. 143, no. 5, pp. 606-612. https://doi.org/10.1001/archderm.143.5.606

Improvement of naturally aged skin with vitamin A (Retinol). / Kafi, Reza; Kwak, Heh Shin R; Schumacher, Wendy E.; Cho, Soyun; Hanft, Valerie N.; Hamilton, Ted A.; King, Anya L.; Neal, Jacqueline D.; Varani, James; Fisher, Gary J.; Voorhees, John J.; Kang, Sewon.

In: Archives of dermatology, Vol. 143, No. 5, 01.05.2007, p. 606-612.

Research output: Contribution to journalArticle

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AU - Kafi, Reza

AU - Kwak, Heh Shin R

AU - Schumacher, Wendy E.

AU - Cho, Soyun

AU - Hanft, Valerie N.

AU - Hamilton, Ted A.

AU - King, Anya L.

AU - Neal, Jacqueline D.

AU - Varani, James

AU - Fisher, Gary J.

AU - Voorhees, John J.

AU - Kang, Sewon

PY - 2007/5/1

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N2 - Objective: To evaluate the effectiveness of topical retinol (vitamin A) in improving the clinical signs of naturally aged skin. Design: Randomized, double-blind, vehicle-controlled, left and right arm comparison study. Setting: Academic referral center. Patients: The study population comprised 36 elderly subjects (mean age, 87 years), residing in 2 senior citizen facilities. Intervention: Topical 0.4% retinol lotion or its vehicle was applied at each visit by study personnel to either the right or the left arm, up to 3 times a week for 24 weeks. Main Outcome Measures: Clinical assessment using a semiquantitative scale (0, none; 9, most severe) and biochemical measurements from skin biopsy specimens obtained from treated areas. Results: After 24 weeks, an intent-to-treat analysis using the last-observation-carried-forward method revealed that there were significant differences between retinol-treated and vehicle-treated skin for changes in fine wrinkling scores (-1.64 [95% CI, -2.06 to -1.22] vs -0.08 [95% CI, -0.17 to 0.01]; P<.001). As measured in a subgroup, retinol treatment significantly increased glycosaminoglycan expression (P=.02 [n=6]) and procollagen I immunostaining (P=.049 [n=4]) compared with vehicle. Conclusions: Topical retinol improves fine wrinkles associated with natural aging. Significant induction of glycosaminoglycan, which is known to retain substantial water, and increased collagen production are most likely responsible for wrinkle effacement. With greater skin matrix synthesis, retinol-treated aged skin is more likely to withstand skin injury and ulcer formation along with improved appearance. Trial Registration: clinicaltrials.gov Identifier: NCT00272610

AB - Objective: To evaluate the effectiveness of topical retinol (vitamin A) in improving the clinical signs of naturally aged skin. Design: Randomized, double-blind, vehicle-controlled, left and right arm comparison study. Setting: Academic referral center. Patients: The study population comprised 36 elderly subjects (mean age, 87 years), residing in 2 senior citizen facilities. Intervention: Topical 0.4% retinol lotion or its vehicle was applied at each visit by study personnel to either the right or the left arm, up to 3 times a week for 24 weeks. Main Outcome Measures: Clinical assessment using a semiquantitative scale (0, none; 9, most severe) and biochemical measurements from skin biopsy specimens obtained from treated areas. Results: After 24 weeks, an intent-to-treat analysis using the last-observation-carried-forward method revealed that there were significant differences between retinol-treated and vehicle-treated skin for changes in fine wrinkling scores (-1.64 [95% CI, -2.06 to -1.22] vs -0.08 [95% CI, -0.17 to 0.01]; P<.001). As measured in a subgroup, retinol treatment significantly increased glycosaminoglycan expression (P=.02 [n=6]) and procollagen I immunostaining (P=.049 [n=4]) compared with vehicle. Conclusions: Topical retinol improves fine wrinkles associated with natural aging. Significant induction of glycosaminoglycan, which is known to retain substantial water, and increased collagen production are most likely responsible for wrinkle effacement. With greater skin matrix synthesis, retinol-treated aged skin is more likely to withstand skin injury and ulcer formation along with improved appearance. Trial Registration: clinicaltrials.gov Identifier: NCT00272610

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Kafi R, Kwak HSR, Schumacher WE, Cho S, Hanft VN, Hamilton TA et al. Improvement of naturally aged skin with vitamin A (Retinol). Archives of dermatology. 2007 May 1;143(5):606-612. https://doi.org/10.1001/archderm.143.5.606