Improving survival by increasing lung edema clearance

Is airspace delivery of dopamine a solution?

Ariel Jaitovich, Jacob I Sznajder*

*Corresponding author for this work

Research output: Contribution to journalComment/debate

4 Citations (Scopus)

Abstract

In this issue of Critical Care Chamorro-Marin and coworkers provide new evidence that dopamine instilled into airspaces is beneficial in a rat model of ventilator-induced lung injury. This study is important because it is the first to explore the effects of dopamine on survival, albeit short term. The delivery of dopamine into the airspaces in vivo is also novel and builds upon previous studies describing the mechanisms by which dopamine exerts its effect by upregulating active Na+ transport in the lungs. Dopamine appears to increase active Na+ transport via activation of amiloride-sensitive sodium channels and the basolateral Na+/K+-ATPase within minutes, and it has been shown to be effective in normal lungs and several models of lung injury. This information is relevant to current clinical trials exploring the effects of alveolar fluid clearance stimulation in patients with acute lung injury.

Original languageEnglish (US)
Article number135
JournalCritical Care
Volume12
Issue number2
DOIs
StatePublished - Apr 15 2008

Fingerprint

Dopamine
Edema
Lung
Survival
Active Biological Transport
Ventilator-Induced Lung Injury
Sodium Channels
Acute Lung Injury
Amiloride
Lung Injury
Critical Care
Clinical Trials

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

@article{49b1e00bcf2143a5a50df05b832b7f49,
title = "Improving survival by increasing lung edema clearance: Is airspace delivery of dopamine a solution?",
abstract = "In this issue of Critical Care Chamorro-Marin and coworkers provide new evidence that dopamine instilled into airspaces is beneficial in a rat model of ventilator-induced lung injury. This study is important because it is the first to explore the effects of dopamine on survival, albeit short term. The delivery of dopamine into the airspaces in vivo is also novel and builds upon previous studies describing the mechanisms by which dopamine exerts its effect by upregulating active Na+ transport in the lungs. Dopamine appears to increase active Na+ transport via activation of amiloride-sensitive sodium channels and the basolateral Na+/K+-ATPase within minutes, and it has been shown to be effective in normal lungs and several models of lung injury. This information is relevant to current clinical trials exploring the effects of alveolar fluid clearance stimulation in patients with acute lung injury.",
author = "Ariel Jaitovich and Sznajder, {Jacob I}",
year = "2008",
month = "4",
day = "15",
doi = "10.1186/cc6825",
language = "English (US)",
volume = "12",
journal = "Critical Care",
issn = "1466-609X",
publisher = "BioMed Central Ltd.",
number = "2",

}

Improving survival by increasing lung edema clearance : Is airspace delivery of dopamine a solution? / Jaitovich, Ariel; Sznajder, Jacob I.

In: Critical Care, Vol. 12, No. 2, 135, 15.04.2008.

Research output: Contribution to journalComment/debate

TY - JOUR

T1 - Improving survival by increasing lung edema clearance

T2 - Is airspace delivery of dopamine a solution?

AU - Jaitovich, Ariel

AU - Sznajder, Jacob I

PY - 2008/4/15

Y1 - 2008/4/15

N2 - In this issue of Critical Care Chamorro-Marin and coworkers provide new evidence that dopamine instilled into airspaces is beneficial in a rat model of ventilator-induced lung injury. This study is important because it is the first to explore the effects of dopamine on survival, albeit short term. The delivery of dopamine into the airspaces in vivo is also novel and builds upon previous studies describing the mechanisms by which dopamine exerts its effect by upregulating active Na+ transport in the lungs. Dopamine appears to increase active Na+ transport via activation of amiloride-sensitive sodium channels and the basolateral Na+/K+-ATPase within minutes, and it has been shown to be effective in normal lungs and several models of lung injury. This information is relevant to current clinical trials exploring the effects of alveolar fluid clearance stimulation in patients with acute lung injury.

AB - In this issue of Critical Care Chamorro-Marin and coworkers provide new evidence that dopamine instilled into airspaces is beneficial in a rat model of ventilator-induced lung injury. This study is important because it is the first to explore the effects of dopamine on survival, albeit short term. The delivery of dopamine into the airspaces in vivo is also novel and builds upon previous studies describing the mechanisms by which dopamine exerts its effect by upregulating active Na+ transport in the lungs. Dopamine appears to increase active Na+ transport via activation of amiloride-sensitive sodium channels and the basolateral Na+/K+-ATPase within minutes, and it has been shown to be effective in normal lungs and several models of lung injury. This information is relevant to current clinical trials exploring the effects of alveolar fluid clearance stimulation in patients with acute lung injury.

UR - http://www.scopus.com/inward/record.url?scp=54049141744&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=54049141744&partnerID=8YFLogxK

U2 - 10.1186/cc6825

DO - 10.1186/cc6825

M3 - Comment/debate

VL - 12

JO - Critical Care

JF - Critical Care

SN - 1466-609X

IS - 2

M1 - 135

ER -