Improving survival by increasing lung edema clearance: Is airspace delivery of dopamine a solution?

Ariel Jaitovich, Jacob Iasha Sznajder*

*Corresponding author for this work

Research output: Contribution to journalComment/debatepeer-review

4 Scopus citations

Abstract

In this issue of Critical Care Chamorro-Marin and coworkers provide new evidence that dopamine instilled into airspaces is beneficial in a rat model of ventilator-induced lung injury. This study is important because it is the first to explore the effects of dopamine on survival, albeit short term. The delivery of dopamine into the airspaces in vivo is also novel and builds upon previous studies describing the mechanisms by which dopamine exerts its effect by upregulating active Na+ transport in the lungs. Dopamine appears to increase active Na+ transport via activation of amiloride-sensitive sodium channels and the basolateral Na+/K+-ATPase within minutes, and it has been shown to be effective in normal lungs and several models of lung injury. This information is relevant to current clinical trials exploring the effects of alveolar fluid clearance stimulation in patients with acute lung injury.

Original languageEnglish (US)
Article number135
JournalCritical Care
Volume12
Issue number2
DOIs
StatePublished - Apr 15 2008

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

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